Oral postmenopausal hormone therapy, C-reactive protein, and cardiovascular outcomes.

Menopause : the Journal of the North American Menopause Society
Emily G KurtzKathryn M Rexrode

Abstract

This study examines C-reactive protein (CRP) levels predicting cardiovascular events (CVEs) among hormone therapy (HT) users and nonusers. CRP levels are higher in women who use oral HT than those in nonusers; however, whether the same CRP cut-points determine increased cardiovascular risk remains unanswered. CRP was measured at baseline in 10,953 HT users and 15,838 nonusers in the Women's Health Study. In HT nonusers and users, Cox proportional hazard models adjusted for age, cardiovascular risk factors, body mass index, and menopause status were constructed using American Heart Association/Centers for Disease Control and Prevention recommended CRP cut-points for low, average, and high cardiovascular risk as well as HT nonuser- and user-derived quantiles of CRP to predict incident CVEs. CVE risk increased with logarithm CRP for both HT users and nonusers. After adjusting for cardiovascular risk factors including lipids, the multivariable relative risk (RR) per log unit of CRP was 1.27 (95% CI, 1.13-1.44) for HT nonusers and 1.22 (95% CI, 1.07-1.40) for HT users. To compare the risk associated with American Heart Association/Centers for Disease Control and Prevention CRP categories across HT use groups, we fit a model in which...Continue Reading

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Citations

Dec 29, 2010·Menopause : the Journal of the North American Menopause Society·Cynthia A Stuenkel
Sep 3, 2013·Journal of the American Society of Hypertension : JASH·Frédérique ThomasMichel E Safar
Dec 25, 2015·Journal of the American College of Cardiology·Martin B MortensenErling Falk
Jun 19, 2013·Endocrine Research·Daniela Celestino SilvaHelio Fernandes Costa
Apr 22, 2011·American Journal of Hypertension·Licy L Yanes, Jane F Reckelhoff
Feb 5, 2019·Climacteric : the Journal of the International Menopause Society·C A Stuenkel
May 1, 2018·Frontiers in Immunology·Nicola R Sproston, Jason J Ashworth
Sep 13, 2012·Menopause : the Journal of the North American Menopause Society·Anand SinglaPaul A Gurbel

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