Oral presentation of posttransplantation lymphoproliferative disorders. An unusual manifestation

Transplantation
D OdaS Aziz

Abstract

Cyclosporine, an immunosuppressive agent widely used in organ transplantation, has several undesirable side effects, including gingival hyperplasia, which occurs in up to 70% of patients. Another complication associated with use of cyclosporine and other immunosuppressants is an increased incidence of malignancies. Long-term use of cyclosporine also is associated with a spectrum of hyperproliferative disorders ranging from reactive lymphoid hyperplasia to aggressive malignant lymphomas. While cyclosporine-related lymphoproliferative disorders have been widely reported, they have not been described in the oral cavity as the first manifestation of this disease. We report on two cardiac transplantation patients with a history of cyclosporine use who presented initially with oral symptoms of lymphoproliferative disorder. Both had erythematous to cyanotic and hyperplastic gingiva. On gingivectomy, the fixed tissue was soft, glistening, and tan colored, in contrast to the usual firm, white, cyclosporine-associated, benign gingival fibrous hyperplasia. Histologically, a dense, diffuse infiltrate of lymphoplasmacytoid cells with vesicular nuclei, prominent nucleoli, a moderate amount of cytoplasm, and high mitotic activity was observed...Continue Reading

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Citations

May 16, 2003·Journal of Periodontology·Laurence BunetelMartine Bonnaure-Mallet
Dec 25, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Sharon EladGail Amir
Sep 1, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ana Carolina Amorim PellicioliPablo Agustin Vargas
Apr 28, 2005·Periodontology 2000·Jørgen Slots
Aug 26, 2009·Oral Microbiology and Immunology·I SaygunJ Slots
Jul 11, 2006·Journal of Periodontal Research·J SlotsA Kubar
Jul 7, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Ayla AkbasKais Hussein
Sep 26, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Alison J BruceLuis A Castro
Apr 30, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Junu OjhaIndraneel Bhattacharyya
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Holly Cole-HawkinsMiranda Pring
Dec 26, 2009·International Journal of Surgical Pathology·Jorge Esquiche LeónMárcio Ajudarte Lopes
Feb 13, 2017·Oral Diseases·J T GuidryR S Scott
Jan 21, 2009·Periodontology 2000·Jørgen Slots
May 16, 2002·Periodontology 2000·Palle Holmstrup, Michael Glick
Sep 11, 2018·Periodontology 2000·Goesta Rutger Persson

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