PMID: 2502251May 20, 1989Paper

Oral rehydration formula containing alanine and glucose for treatment of diarrhoea: a controlled trial

BMJ : British Medical Journal
F C PatraR N Mazumder

Abstract

To determine whether adding L-alanine to the glucose based oral rehydration solution recommended by the World Health Organisation would improve its efficacy in treating acute diarrhoea. Randomised double blind controlled trial of oral rehydration solution containing L-alanine and glucose. Inpatient service of a hospital treating diarrhoea. 97 Male patients aged 6-59 years admitted to the hospital with acute and severe dehydration due to diarrhoea associated with Vibrio cholerae or enterotoxigenic Escherichia coli. Forty nine received the standard glucose based oral rehydration solution (control group) and 48 this solution with alanine added (study group). All of the patients received rapid intravenous acetate solution for the initial four hours after admission, which fully corrected the signs of dehydration. They were then admitted to the study and randomised. Immediately after the intravenous treatment oral rehydration treatment was started. All of the patients received oral tetracycline for 48 hours, starting 24 hours after start of the study. If signs of dehydration reappeared during oral treatment patients were given rapid intravenous acetate solution until they were fully corrected and then continued to take the assigned o...Continue Reading

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