Oral Rifampin treatment for longstanding chronic central serous chorioretinopathy

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Shiri ShulmanMichaella Goldstein

Abstract

To investigate the effect of oral Rifampin in patients with chronic central serous chorioretinoapthy (CSCR). This was a prospective pilot study of patients with chronic CSCR with persistent subretinal fluid (SRF) for at least 3 months, who were treated with oral Rifampin 300 mg twice per day for 3 months and had 6 months of follow-up. All patients underwent a complete ocular examination and a spectral domain optical coherence tomography (SD-OCT) scan monthly from baseline until month 4, and then at month 6. Fluorescein angiography (FA) was performed at baseline and at the end of the study. Fourteen eyes of 12 patients were included in the study, nine men and three women. Mean age was 58.5 years (range 32-80). Mean duration of SRF prior to study entry was 28.4 months. Forty-two percent of eyes were treated previously for CSR with thermal laser, PDT, or intravitreal bevacizumab. Mean best corrected visual acuity (BCVA) at presentation was 20/60 and improved to a mean of 20/50 at month 3 (P > 0.05). Retinal thickness was reduced by 25.3 %, 21.2 %, and 21 % on months 1, 2, 3, respectively (P < 0.05). Mean choroidal thickness at presentation was 476 μ (SD 188 μ) decreasing to 427 μ (SD 125 μ) after 3 months of treatment (P > 0.05). ...Continue Reading

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Citations

Jan 25, 2019·Current Pharmaceutical Design·Pierluigi IaconoMaria Cristina Parravano
Aug 12, 2017·Current Ophthalmology Reports·Brian E Goldhagen, Raquel Goldhardt
Mar 25, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·UNKNOWN Berufsverband der Augenärzte Deutschlands e. V. (BVA)UNKNOWN Retinologische Gesellschaft e. V. (RG)
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Jun 28, 2021·Survey of Ophthalmology·Supriya AroraJay Chhablani
Nov 21, 2019·Archives of Medical Science : AMS·Arkadiusz HoffmannRafał Pawliczak

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