Oral ritodrine maintenance in the treatment of preterm labor

American Journal of Obstetrics and Gynecology
R K CreasyJ M Roberts

Abstract

Seventy patients with preterm labor and intact membranes were initially treated with ritodrine hydrochloride to delay preterm delivery. Tocolysis beyond 24 hours was achieved in 59 patients. Fifty-five of the 59 patients were then placed on either oral ritodrine or placebo as maintenance therapy in a randomized double-blind manner. If preterm labor recurred, the sequence of intramuscular and then oral treatment was repeated. The number of days gained after initiation of intramuscular treatment was similar in both groups (oral ritodrine = 34 days, oral placebo = 36 days). In those 55 patients receiving oral treatment, there was a smaller number of relapses requiring repeat intramuscular treatment in the oral ritodrine group (1.11 in the ritodrine patient vs. 2.71 in the placebo patient, p less than 0.05), and the mean interval between beginning oral treatment and the first relapse/delivery was 5.8 days in the oral placebo group and 25.9 in those receiving oral ritodrine (p less than 0.05). Cardiovascular side effects, notably maternal tachycardia and palpitations were frequent but well tolerated. The results suggest that oral ritodrine maintenance will decrease the incidence of recurrent preterm labor in patients who have had in...Continue Reading

Citations

Mar 1, 1988·British Journal of Obstetrics and Gynaecology·J F KingI Chalmers
Jul 1, 1996·British Journal of Obstetrics and Gynaecology·C A HolleboomM J Keirse
Aug 27, 2014·Drug and Chemical Toxicology·Ayper Boğa PekmezekmekBesim Özaykan
Jul 1, 1986·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R F Lamont, M G Elder
Nov 13, 1998·Obstetrical & Gynecological Survey·F LamR Willcourt
Feb 24, 2001·The Journal of Pharmacy and Pharmacology·N Shinkai, S Takayama
Apr 22, 2008·Expert Opinion on Pharmacotherapy·K Y Ronald Kam, Ronald F Lamont
Jul 12, 2012·Drug Development and Industrial Pharmacy·Osamu Sakata, Hiraku Onishi
Jun 1, 1984·Postgraduate Medicine·R H Holbrook, R K Creasy
Apr 1, 1984·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·N G TchilinguirianF J Craparo
Jul 30, 1992·The New England Journal of Medicine·UNKNOWN Canadian Preterm Labor Investigators Group
May 1, 1984·British Journal of Obstetrics and Gynaecology·M J Keirse
Nov 1, 1983·British Journal of Obstetrics and Gynaecology·L J Downey, A J Martin
Sep 19, 2006·Pharmacoepidemiology and Drug Safety·Yukari Yaju, Takeo Nakayama
May 10, 2002·Obstetrical & Gynecological Survey·Sheryl Rodts-Palenik, John C Morrison
Jul 16, 1999·The Journal of Maternal-fetal Medicine·N B MeirowitzA M Vintzileos
Feb 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·James G Thornton
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Jodie M DoddPhilippa Middleton
Jul 1, 1992·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J C MorrisonK S Gookin
Feb 28, 2002·Clinical Obstetrics and Gynecology·Arun Jeyabalan, Steve N Caritis
Apr 12, 2013·Obstetrics and Gynecology International·John P Elliott, John C Morrison
Jun 4, 2019·American Journal of Obstetrics and Gynecology·Roberto Romero

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