Oral selenium supplementation has no effect on prostate-specific antigen velocity in men undergoing active surveillance for localized prostate cancer.

Cancer Prevention Research
M Suzanne StrattonFrederick R Ahmann

Abstract

The Nutritional Prevention of Cancer trial showed a 52% lower incidence of prostate cancer in men supplemented with selenium. As a result, our study was designed to assess whether selenium supplementation attenuates the progression of prostate cancer. A phase 2 randomized, double-blind, placebo-controlled clinical trial was conducted in men with localized nonmetastatic prostate cancer who had elected to forgo active treatment and be followed by active surveillance. A total of 140 men were randomized to placebo (n = 46), 200 microg/d (n = 47), or 800 microg/d (n = 47) selenium p.o. (as selenized yeast) and followed every 3 months for up to 5 years. Prostate-specific antigen (PSA) velocity was used as a marker of prostate cancer progression and was estimated using mixed-effects regression. Adjusting for age, body mass index, baseline selenium, smoking, baseline PSA, race, PSA method, and Gleason score, PSA velocities for the 200 microg/d and 800 microg/d treatment groups were not statistically significantly different from placebo (P = 0.32 and P = 0.61, respectively). In the highest quartile of baseline selenium, men supplemented with 800 microg selenium showed statistically significantly higher PSA velocity as compared with plac...Continue Reading

References

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Citations

Dec 17, 2014·Journal of the National Cancer Institute·Stacey A KenfieldJune M Chan
Jul 8, 2016·Journal of the National Cancer Institute·Naomi E AllenUNKNOWN Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group
May 27, 2011·American Journal of Men's Health·Amit M AlgotarPatricia A Thompson
Oct 23, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel PlanoCarmen Sanmartín
Jan 30, 2018·The Cochrane Database of Systematic Reviews·Marco VincetiCatherine M Crespi
Mar 23, 2013·Current Opinion in Oncology·Howard L ParnesJoseph A Tangrea
Jul 23, 2019·Urologic Oncology·Kyle B ZunigaStacey A Kenfield
Oct 17, 2020·BioMed Research International·Chenglin HanXunbo Jin

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