PMID: 6405419Jan 1, 1983Paper

Oral self-administration of methohexital in baboons

Psychopharmacology
N A Ator, R R Griffiths

Abstract

Oral self-administration of methohexital was generated in baboons that were food-restricted but not water-deprived. Stable intake of an 8% ethanol solution (two baboons) or water (two baboons) was first established in 3-h-sessions. Increasing concentrations of methohexital (0.005-10 mg/ml) then were substituted with a return to the ethanol or water baseline condition between methohexital conditions. For one baboon in the ethanol baseline condition, drinking was initially suppressed by methohexital substitution, but increased under a food-induced drinking procedure. For all baboons, an inverted U-shaped function generally described the relation between methohexital concentration and volume consumed. Anesthetization was observed at concentrations of 1.6 mg/ml and above. In two-bottle choice tests, three baboons generally drank greater volumes of methohexital than water at concentrations of 0.8 mg/ml and above. After a methohexital-free period of 1-3 months methohexital self-administration was readily reestablished.

References

Dec 8, 1978·Psychopharmacology·M E Carroll, R A Meisch
Sep 1, 1977·Pharmacology, Biochemistry, and Behavior·R A Meisch, L J Stark
Aug 1, 1973·Neuropharmacology·R P Maickel, G J Maloney
Jan 1, 1973·Pharmacology, Biochemistry, and Behavior·N K Mello
Jan 1, 1981·Psychopharmacology·R R GriffithsJ D Snell
Apr 1, 1981·Drug and Alcohol Dependence·J E HenningfieldR R Griffiths
Apr 1, 1953·Journal of Experimental Psychology·C B FERSTER

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Citations

Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·N A Ator, R R Griffiths
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·D J SpearJ L Katz
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R R GriffithsJ V Brady
May 22, 2003·Drug and Alcohol Dependence·Nancy A Ator, Roland R Griffiths
Jun 18, 2004·Alcoholism, Clinical and Experimental Research·Simon N KatnerMichael A Taffe
May 1, 2008·Alcoholism, Clinical and Experimental Research·Michael R WeedRobert D Hienz

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