Oral squamous cancer cell exploits hnRNP A1 to regulate cell cycle and proliferation

Journal of Cellular Physiology
Cheng YuMingwen Fan

Abstract

Oral squamous cell carcinoma (OSCC) is a common human malignant tumor with high mortality. So far, the molecular pathogenesis of OSCC remains largely unclear. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an important multi-function splicing factor and closely related to tumorigenesis. hnRNP A1 is overexpressed in various tumors, and promotes aerobic glycolysis and elongation of telomere, but the function of hnRNP A1 in cell cycle and proliferation remains unclear. We found that hnRNP A1 was overexpressed in OSCC tissues, and was required for the growth of OSCC cells. Moreover, hnRNP A1 was highly expressed in the G2/M cell cycle phase. Knockdown of hnRNP A1 induced G2/M arrest. DNA microarray assay result showed that hnRNP A1 regulated the expression of a number of target genes associated with G2/M phase. Moreover, hnRNP A1 controlled the alternative splicing of CDK2 exon 5. These findings suggested that hnRNP A1 plays key roles in the regulation of cell cycle progression and pathogenesis of OSCC.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J RosenblattD O Morgan
Dec 23, 1988·Nucleic Acids Research·S R PlanckS D Buckley
Jan 1, 1993·Annual Review of Biochemistry·G DreyfussC G Burd
Jun 14, 1996·Journal of Molecular Biology·L CartegniG Biamonti
Jul 8, 1999·Current Opinion in Cell Biology·A M Krecic, M S Swanson
Mar 9, 2002·Molecular and Cellular Biology·Angela IervolinoDanilo Perrotti
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·R ToddD T Wong
Jul 23, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Irene PinoLuis M Montuenga
Aug 19, 2003·Nature Genetics·Sagrario OrtegaMariano Barbacid
Sep 25, 2003·Cell Cycle·Helder MaiatoClaudio E Sunkel
Jul 15, 2005·Journal of Cell Science·Yaowu HeRoss Smith
Dec 28, 2005·Biochimica Et Biophysica Acta·Brian CarpenterGraeme I Murray
Mar 20, 2009·Genome Biology·Martin AkermanYael Mandel-Gutfreund
May 22, 2009·Nucleic Acids Research·Timothy L BaileyWilliam S Noble
Jun 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jan J MolenaarHuib N Caron
Sep 8, 2009·Nature Cell Biology·Marina MelixetianKristian Helin
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cynthia V ClowerAdrian R Krainer
Feb 9, 2010·Developmental Biology·Elim HongRachel Brewster
May 27, 2010·Nucleic Acids Research·Inbal PazYael Mandel-Gutfreund
Dec 15, 2010·Cell Structure and Function·Nobuhisa IshidaKohji Takei
Dec 24, 2010·International Journal of Biological Sciences·Rong JiaZhi-Ming Zheng
Jul 29, 2011·The FEBS Journal·Laure TwyffelsVéronique Kruys
Jan 28, 2012·Journal of Proteomics·Pablo R GrigeraJay W Fox
Nov 13, 2012·Retrovirology·Denitra BreuerSergei Nekhai
May 15, 2013·Biochemical and Biophysical Research Communications·Yasuyuki Kaneta, Axel Ullrich
Sep 26, 2013·International Journal of Molecular Sciences·Jacques Jean-PhilippeMassimo Caputi

❮ Previous
Next ❯

Citations

Apr 14, 2018·Genome Research·Jonathan M HowardJeremy R Sanford
Aug 23, 2018·Journal of Cellular Physiology·Jihua Guo, Rong Jia
Feb 9, 2018·Cell Division·Steven BoeynaemsLudo Van Den Bosch
Aug 10, 2017·Wiley Interdisciplinary Reviews. RNA·Rajat RoyOlivier E Pardo
Jul 1, 2020·Frontiers in Cell and Developmental Biology·Andrea CerasuoloMaria Lina Tornesello
Feb 13, 2021·Journal of Experimental & Clinical Cancer Research : CR·Hui-Er ZhuHui Chen
Jul 1, 2021·Omics : a Journal of Integrative Biology·Akhina PalollathilThottethodi Subrahmanya Keshava Prasad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Lei-Ya FangYuh-Ling Chen
© 2022 Meta ULC. All rights reserved