Oral Submucous Fibrosis as an Overhealing Wound: Implications in Malignant Transformation

Recent Patents on Anti-cancer Drug Discovery
Mohit SharmaRaghu Radhakrishnan

Abstract

Oral submucous fibrosis is an oral potentially malignant disorder with high incidence of malignant transformation and rising global prevalence. However, the genesis of oral submucous fibrosis is still unclear despite superfluity of literature. In the background of ineffective treatment, it is necessary to decode its onset and progression before designing customized treatment regimens. The objective of this article is to decipher the pathogenesis of oral submucous fibrosis in order to identify novel drug targets. A thorough literature review based on oral submucous fibrosis being an overhealing wound was conducted; several related patents were identified and herewith reviewed. Necessary pathways were elaborated and deliberated in the manuscript in the form of schemas, keeping our hypothesis in mind. Several novel molecular targets were identified and discussed in detail. Several patents demonstrating inhibition of fibrosis via chemokine ligand mimetics, anticonnexon antibodies, stem cell therapy, fibronectin blocking peptides, HIF inhibitors, recombinant erythropoietin, xanthine oxidase inhibitors, long non-coding RNAs, targeting inflammation, increasing TH-1/TH-2 cytokine ratio, t-box protein 4, chromium containing compositions...Continue Reading

Citations

Aug 23, 2020·International Journal of Oral Science·Mohit SharmaRaghu Radhakrishnan
Sep 14, 2019·Journal of International Society of Preventive & Community Dentistry·Vikash K JhaAtul A Bajoria
Jun 19, 2019·International Journal of Molecular Sciences·Yin-Hwa ShihYu-Hsin Tseng
Dec 12, 2020·International Journal of Environmental Research and Public Health·Silvio AbatiMatteo Trimarchi
Oct 30, 2020·Journal of Oral Biology and Craniofacial Research·Toniya RautAshish Shrestha

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