Oral sucrose for heel lance enhances adenosine triphosphate use in preterm neonates with respiratory distress

SAGE Open Medicine
Danilyn M AngelesElba Fayard

Abstract

To examine the effects of oral sucrose on procedural pain, and on biochemical markers of adenosine triphosphate utilization and oxidative stress in preterm neonates with mild to moderate respiratory distress. Preterm neonates with a clinically required heel lance that met study criteria (n = 49) were randomized into three groups: (1) control (n = 24), (2) heel lance treated with placebo and non-nutritive sucking (n = 15) and (3) heel lance treated with sucrose and non-nutritive sucking (n = 10). Plasma markers of adenosine triphosphate degradation (hypoxanthine, xanthine and uric acid) and oxidative stress (allantoin) were measured before and after the heel lance. Pain was measured using the Premature Infant Pain Profile. Data were analyzed using repeated measures analysis of variance, chi-square and one-way analysis of variance. We found that in preterm neonates who were intubated and/or were receiving ⩾30% FiO2, a single dose of oral sucrose given before a heel lance significantly increased markers of adenosine triphosphate use. We found that oral sucrose enhanced adenosine triphosphate use in neonates who were intubated and/or were receiving ⩾30% FiO2. Although oral sucrose decreased pain scores, our data suggest that it als...Continue Reading

References

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Feb 19, 2013·The Journal of Pediatrics·Yayesh AsmeromDanilyn M Angeles

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Citations

Feb 28, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Danilyn M AngelesElba Fayard

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BETA
blood draws

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SPSS Statistics

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