Oral Supplementation With Bovine Colostrum Prevents Septic Shock and Brain Barrier Disruption During Bloodstream Infection in Preterm Newborn Pigs

Shock
Anders BrunsePer T Sangild

Abstract

Preterm infants have increased risk of neonatal sepsis, potentially inducing brain injury, and they may benefit from early initiation of enteral milk feeding. Using preterm pigs as models, we hypothesized that early provision of bovine colostrum to parentally nourished newborns protects against sepsis and neuroinflammation during bloodstream infection. Preterm newborn pigs were administered 10 CFU/kg of intra-arterial Staphylococcus epidermidis (SE, an opportunistic pathogen often causing sepsis in preterm infants), followed by administration of total parenteral nutrition (TPN, SE + TPN, n = 15) or oral provision of bovine colostrum with supplementary parenteral nutrition (SE + COL, n = 14), and compared with uninfected, TPN-nourished controls (CON + TPN, n = 11). SE-infected animals showed multiple signs of sepsis, including lethargy, hypotension, respiratory acidosis, internal organ hemorrhages, cellular responses (leukopenia, thrombocytopenia), brain barrier disruption, and neuroinflammation. At 24 h, colostrum supplementation reduced the SE abundance in blood and cerebrospinal fluid (CSF, both P < 0.05). Furthermore, colostrum feeding normalized arterial blood pressure (38.5 ± 1.20 vs. 30.6 ± 3.79 mmHg), pH (7.37 ± 0.02 vs....Continue Reading

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Citations

Nov 27, 2018·Shock·Hongkuan Fan, Andrew J Goodwin
Dec 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Masoumeh AlinaghiJohan A Westerhuis
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May 20, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shuqiang RenDuc Ninh Nguyen
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Aug 28, 2021·Nutrients·Per Torp SangildDouglas G Burrin
May 30, 2019·Developmental Neuroscience·Charlotte Holme NielsenPer Torp Sangild

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