PMID: 8964917May 1, 1996Paper

Oral tolerance in EAE: reversal of tolerance by T helper cell cytokines

Journal of Neuroimmunology
K A Kelly, C C Whitacre

Abstract

Oral administration of myelin basic protein (MBP) inhibits clinical and histopathological manifestations of experimental autoimmune encephalomyelitis (EAE), but only partially reduces serum anti-MBP antibody titers. We report here that orally administered MBP alters the isotypic distribution of anti-MBP antibody-forming cells (AFC) among various lymphoid tissues, with the most profound differences seen in mucosal tissues. We observed an isotype-selective reduction in anti-MBP IgA but not IgM AFC frequencies in Peyer's patches. The anti-MBP IgA AFC frequencies could be reconstituted by addition of interleukin 4 (IL-4) and interleukin 5(IL-5). The cytokines did not appear to generate de novo responses since no increases in anti-MBP lgA AFC frequencies were observed in control cultures. These results indicate that decreased antibody production, as a result of oral antigen administration, can be reversed by exposure to the appropriate cytokines.

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Citations

May 20, 1998·Research in Immunology·J M Benson, C C Whitacre
Apr 9, 2001·Clinical Microbiology Reviews·P L OgraR C Welliver
Jun 1, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kaja KasarelloAgnieszka K Szczepankowska
Feb 13, 2013·Cellular Immunology·Archimedes Barbosa Castro-JuniorNelson Monteiro Vaz
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D A KahnC J Kelly
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen M SmithPaul Garside
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R B Fritz, M L Zhao

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