PMID: 8610975Feb 13, 1996Paper

Oral tolerance in experimental autoimmune encephalomyelitis

Annals of the New York Academy of Sciences
C C WhitacreN Javed

Abstract

In work performed by a number of laboratories, it has become quite clear that the oral administration of autoantigens exerts a profoundly suppressive effect on the development and long-term clinical course of autoimmune disease. Specific peptide sequences derived from the autoantigens are similarly suppressive. An interesting sidelight to emerge from specificity studies is that oral administration of a self-protein or peptide sequence (i.e., rat MBP peptide administered to a rat) is markedly less tolerogenic than oral administration of a non-self or even closely related sequence (guinea pig MBP peptide administered to a rat). The dose of oral antigen is now known to play a critical role in determination of the mechanism of oral tolerance, with low doses of antigen causing active suppression with concomitant release of TGFbeta1. Studies outlined here suggest that oral administration of higher antigen doses (e.g., 20 mg MBP to rats or mice) results in deletion of specific antigen-reactive T lymphocytes. This conclusion stems from the fact that injections of IL-2 could not reverse high-dose tolerance while reversing low-dose oral tolerance. Moreover, feeding MBP to MBP-TCR transgenic mice caused trafficking of transgenic cells to ...Continue Reading

References

Oct 1, 1991·The Journal of Experimental Medicine·A MillerH L Weiner
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C Nagler-AndersonG J Thorbecke

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Citations

Feb 1, 2005·Annals of the New York Academy of Sciences·Norman A StainesJohn J Murphy
Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Oct 8, 2008·Trends in Immunology·Joan Stein-Streilein
May 22, 2002·Annals of the New York Academy of Sciences·Stephan Strobel
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rifaat SafadiScott L Friedman
Jan 1, 1997·Rheumatology International·U GimsaN A Mitchison
Aug 22, 2003·Oral Microbiology and Immunology·W SosrosenoG J Seymour
Oct 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niannian JiThomas G Forsthuber
Jun 19, 2002·The Proceedings of the Nutrition Society·S Strobel
Aug 24, 2004·Infection and Immunity·Mairi C NoverrGary B Huffnagle
Apr 1, 1997·Immunological Reviews·A M Mowat, J L Viney
Feb 6, 1998·Journal of Neuroscience Research·S Goldman-BrezinskiC Whitacre
Jan 3, 2001·Journal of the American Society of Nephrology : JASN·John Reynolds, Charles D Pusey

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