PMID: 6693168Feb 1, 1984

Oral toxicities of Clostridium botulinum type A and B toxins from different strains

Infection and Immunity
I Ohishi

Abstract

The production and the oral toxicity for mice of Clostridium botulinum type A and B toxins of different strains were studied. All five type B strains produced both 16S (large or L) and 12S (medium or M) toxins, although the relative amounts varied with the strains. The culture supernatant of type B Okra strain was the most potent in oral toxicity. The L toxin of this culture was about 700 times more toxic in feeding tests with mice than the L toxin from type B strain NH-2, whereas the M toxins of the two strains had the same oral toxicity. These results indicate that the oral toxicity of type B toxin varies with the culture strain. Oral toxicities of L toxin produced by type A strains 62A and 97 were comparable but were 10 times higher than those of their M toxins. Hybrids of toxic and nontoxic components separated from L toxins of type B strains Okra and NH-2 revealed that the high oral toxicity of the B-L toxin of strain Okra is attributable not to the toxic but to the nontoxic component of the toxin. The present study suggests that the 16S molecular-sized toxin elaborated by a certain strain of C. botulinum type B is implicated in the high fatality rate in type B human botulism.

Citations

Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Lance L Simpson
Feb 7, 2007·Expert Review of Vaccines·Kohtaro FujihashiDavid W Pascual
Jan 12, 2011·FEMS Immunology and Medical Microbiology·Hiroaki ItoToshihiro Watanabe
Apr 5, 2008·Disaster Medicine and Public Health Preparedness·Zygmunt F DembekJanice M Rusnak
Mar 21, 2019·Animal Models and Experimental Medicine·James R Swearengen

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