Oral treatment of hemophilia A using traditional kanpo medicine, Huang-lien-chieh-tu-tang (plant extract)

Haemostasis
A Adachihara

Abstract

Huang-lien-chieh-tu-tang (HLCT) extract was given orally to a patient with severe hemophilia A. The plasma concentration of factor VIII rose from less than 1 to 41% 1 h after oral administration of HLCT extract. APTT also decreased from 102.0 to 70.9 s. In vitro experiments, HLCT showed factor VIII, IX and X biological activity at concentrations around 0.08%. There was no factor-VIII-antigen-related activity in HLCT.

Citations

Jan 7, 2010·The Angle Orthodontist·Goksu Trakyali, M Oguz Oztoprak
Jan 17, 2014·Journal of Maxillofacial and Oral Surgery·Yogesh K KiniJitendra V Kalburge

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