Oral treatment with Bifidobacterium longum 51A reduced inflammation in a murine experimental model of gout

Beneficial Microbes
A T VieiraF S Martins

Abstract

Gout is an acute inflammatory disease characterised by the presence of uric acid crystals in the joint. This event promotes neutrophil infiltration and activation that leads to tissue damage. We investigated here whether the oral administration of the probiotic strain Bifidobacterium longum 5(1A) (BL) could ameliorate monosodium urate crystal (MSU)-induced inflammation in a murine model of gout. Mice received oral administration of BL or saline daily for 7 days and then were injected with MSU in the knee cavity. Treatment with BL significantly alleviated the inflammatory parameters, as seen by reduced hypernociception, reduced neutrophil accumulation in the joint and myeloperoxidase activity in periarticular tissue. There was inhibition of the production of CXCL1 and interleukin(IL)-1β in joints. Levels of the anti-inflammatory cytokine IL-10 were significantly higher in the knee tissue of mice treated with than control mice injected with MSU. In conclusion, oral BL treatment reduced the inflammatory response in an experimental murine model of gout, suggesting it may be useful as an adjuvant treatment in patients with gout.

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Citations

Dec 1, 2015·Frontiers in Pharmacology·Bhanu Priya Ganesh, James Versalovic
Oct 21, 2016·Clinical & Translational Immunology·Angélica Thomaz VieiraCaroline Marcantonio Ferreira
May 2, 2018·Journal of Nutritional Science and Vitaminology·Dwi Eva NirmagustinaNorihisa Kato
Dec 20, 2017·Frontiers in Microbiology·Lorena RuizAbelardo Margolles
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Jun 22, 2021·Gene·Jéssica Gabrielle Vidal da SilvaAnne Cybelle Pinto Gomide
Sep 25, 2021·Probiotics and Antimicrobial Proteins·Spencer S SantosFlaviano S Martins

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