Oral valganciclovir as pre-emptive therapy has similar efficacy on cytomegalovirus DNA load reduction as intravenous ganciclovir in allogeneic stem cell transplantation recipients

Bone Marrow Transplantation
P L J van der HeidenE F Schippers

Abstract

The efficacy and safety of oral valganciclovir was compared to ganciclovir i.v. in pre-emptive treatment of cytomegalovirus (CMV) in T-cell-depleted allogeneic stem cell transplant (allo-SCT) recipients. A therapeutic guideline was developed to allow the safe application of valganciclovir in allo-SCT recipients requiring CMV therapy. In total, 107 consecutive transplant recipients were evaluated. Cytomegalovirus DNA load in plasma was monitored longitudinally; details on antiviral therapy and treatment responses were analyzed retrospectively. Fifty-seven CMV treatment episodes were recorded in 34 patients: 20 with valganciclovir (900 mg twice-daily) and 37 with ganciclovir (5 mg/kg twice-daily). Median CMV DNA load reduction was 0.079 and 0.069 log10 copies/ml/day in the ganciclovir and valganciclovir group, respectively. Good response on CMV DNA load (reduction below 3.0 log10 copies/ml) was observed in 75.7% of ganciclovir and 80.0% of valganciclovir treatment episodes. Severe adverse effects were not observed and CMV-related disease did not occur. However, the percentage of patients receiving erythrocyte transfusion was higher in the group of patients receiving ganciclovir as compared to valganciclovir (41 versus 20%, P=0.11...Continue Reading

References

Aug 1, 1980·The American Journal of Medicine·H M ShulmanE D Thomas
Feb 1, 1993·Annals of Internal Medicine·J M GoodrichJ D Meyers
Sep 5, 1996·The New England Journal of Medicine·C S Crumpacker
Aug 6, 1999·Journal of Clinical Pharmacology·D Jung, A Dorr
Sep 19, 2000·Antimicrobial Agents and Chemotherapy·M D PescovitzF Brown
Mar 23, 2001·Reviews in Medical Virology·G D Hart, C V Paya
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanCarlos Paya
Sep 28, 2002·The Journal of Infectious Diseases·Per Ljungman
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Carlos PayaUNKNOWN Valganciclovir Solid Organ Transplant Study Group
Nov 13, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Elena DevyatkoMichael Grimm
Nov 30, 2004·The Lancet Infectious Diseases·Maher K Gandhi, Rajiv Khanna
Apr 12, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Raymund R Razonable

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Citations

Jan 17, 2009·International Journal of Hematology·Katsuto TakenakaUNKNOWN for Fukuoka Blood and Marrow Transplant Group (FBMTG)
Jul 1, 2008·Bone Marrow Transplantation·P LjungmanUNKNOWN European Conference on Infections in Leukemia
Sep 8, 2011·International Ophthalmology Clinics·Anthony B DanielsLucy H Y Young
Mar 11, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Clara C PosthumaAloys C M Kroes
Jul 30, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Hubertus C E BuyckVincent C Emery
Oct 29, 2015·Immunotherapy·Taiga NishihoriMohamed A Kharfan-Dabaja
Oct 11, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D FocosiM Petrini
Jul 21, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A AsbergUNKNOWN VICTOR Study Group
May 8, 2013·British Journal of Haematology·Vincent EmeryUNKNOWN UK Virology Network
Apr 27, 2012·British Journal of Haematology·Fiona L DignanUNKNOWN British Society for Blood and Marrow Transplantation
May 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Pau MontesinosGuillermo F Sanz
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcie TomblynUNKNOWN Centers for Disease Control and Prevention
Oct 15, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Shivaprasad ManjappaRizwan Romee
Jan 7, 2017·Journal of Pediatric Hematology/oncology·Bethany A WattlesJoshua J Elder
Oct 9, 2019·Current Opinion in Oncology·Gaurav Sutrave, David J Gottlieb
Feb 25, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Yukiko MisakiYoshinobu Kanda
Jan 31, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chieh-Lin Jerry TengBor-Sheng Ko
Jul 27, 2021·Current Treatment Options in Infectious Diseases·Niyati JakhariaDavid J Riedel

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