Oral vinorelbine-based concomitant chemoradiotherapy in unresectable stage III non-small cell lung cancer: a systematic review

Expert Review of Anticancer Therapy
Paul LesueurChristos Chouaid

Abstract

Cisplatin-based chemotherapy administered concomitantly to thoracic radiotherapy is the treatment recommended by the European guidelines for fit patients with unresectable stage III non-small cell lung cancer (NSCLC). Cisplatin may be combined with etoposide, vinorelbine or other vinca alkaloids, which act also as radiation sensitizers. Initially administered intravenously, vinorelbine is also available as oral formulation and is the only orally available microtubule-targeting agent. In addition, the oral formulation avoids the risk of extravasation and phlebitis. Areas covered: A literature search has been performed for articles reporting phase II-III trials aimed to evaluate efficacy and safety of oral vinorelbine-based chemoradiotherapy in unresectable locally advanced NSCLC. Expert commentary: In a series of trials with various protocols published from 2008 to 2018, mostly phase II studies, oral vinorelbine demonstrated a significant activity in concomitant chemoradiotherapy for unresectable locally advanced NSCLC typically as part of combination schedules with cisplatin. Main toxicities were hematologic (neutropenia and anemia); non-hematological toxicities included esophagitis and gastro-duodenal adverse events. Large pro...Continue Reading

References

Sep 15, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Petr ZatloukalLadislav Pecen
Aug 3, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomoyuki GoyaUNKNOWN Japanese Joint Committee of Lung Cancer Registry
Aug 23, 2005·Expert Opinion on Drug Safety·Vittorio Gebbia, Christian Puozzo
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ikuo SekineTomohide Tamura
Sep 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Maciej KrzakowskiPhilippe David
Jun 2, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Swan Swan LeongEng Huat Tan
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Aug 11, 2010·Cancer Chemotherapy and Pharmacology·Athanasios G PallisVassilis Georgoulias
Dec 18, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Renaud DescourtUNKNOWN GFPC VINCR Team
May 9, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hans H StrømUlf Aasebø
Jun 29, 2014·Expert Opinion on Pharmacotherapy·Giulia BarlettaFrancesco Grossi
Nov 15, 2014·Future Oncology·Giovenzio GenestretiAlba A Brandes
Feb 7, 2015·Critical Reviews in Oncology/hematology·Antonio GnoniVito Lorusso
Apr 22, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W E E EberhardtUNKNOWN Panel Members
Dec 23, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Pierre FournelUNKNOWN GFPC and IFCT team
Apr 16, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Olfred HansenTine Schytte
Sep 9, 2017·The New England Journal of Medicine·Scott J AntoniaUNKNOWN PACIFIC Investigators

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Citations

Aug 21, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C R ArnoldS Skvortsov

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