Oral vitamin D3 supplementation for chronic plaque psoriasis: a randomized, double-blind, placebo-controlled trial

The Journal of Dermatological Treatment
Michelle A IngramPamela R von Hurst

Abstract

The management of psoriasis remains a challenge for dermatologist and patient. This study aimed to determine whether vitamin D3 supplementation improves psoriasis compared to placebo. In a randomized, doubled-blind, placebo-controlled trial, 101 participants ≥18 years with psoriasis were grouped by severity and allocated to 100,000 International Units (IU) vitamin D3/month for 12 months (200,000 IU at baseline; n = 67) or an identical placebo (n = 34). Psoriasis Area and Severity Index (PASI) and serum 25(OH)D concentrations were assessed at 3-monthly intervals. The primary outcome was the difference in PASI between groups over time. The relationship between 25(OH)D and PASI across the sample was also considered in a post hoc analysis. PASI did not differ between groups at any time (group F(1, 104) = 0.48, p = .49; group*time F(4, 384) = 0.26, p = .90). However, 25(OH)D increased in both groups, rendering these findings inconclusive. A significant inverse relationship existed between PASI and 25(OH)D, with elevation of 25(OH)D by up to 125 nmol/L associated with mild decreases in PASI (estimated range of decrease 0-2.6; p = .002). A direct benefit of vitamin D3 supplementation for psoriasis could not be determined. However, the...Continue Reading

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Citations

May 30, 2019·Dermatology Research and Practice·Wareeporn DisphanuratPadcha Pongcharoen
Jul 19, 2020·Nutrients·Nipith Charoenngam, Michael F Holick
Jan 10, 2021·Nutrients·Ana Maria Alexandra StanescuCamelia Cristina Diaconu
May 4, 2020·Journal of the American Academy of Dermatology·Katherine G Thompson, Noori Kim
Sep 26, 2021·AAPS PharmSciTech·Sudeep Sudesh PukaleDeepak Chitkara

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