Oral vs inhaled asthma therapy. Pros, cons and combinations

Drugs
L M FabbriA Ciaccia

Abstract

A number of oral and inhaled drugs are available for the long term management of patients with persistent asthma, yet the disease continues to be associated with significant morbidity and mortality. Over the past years, inhaled glucocorticoids have become established as a cornerstone of maintenance therapy because of their demonstrated clinical efficacy, ability to reduce bronchial inflammation and good tolerability. Other inhaled drugs (e.g. sodium cromoglycate, nedocromil, long-acting beta 2 agonists) also play a role in the long term treatment of patients with asthma. However, many patients (especially children and the elderly) find inhalers difficult to use, and poor inhalation technique can affect the amount of drug reaching the lungs and response to therapy. Oral drug administration is simple, but, until recently, oral asthma therapy has primarily consisted of sustained-release theophylline and glucocorticoids. Theophylline has a narrow therapeutic index, necessitating regular monitoring of serum drug concentrations, and long term oral glucocorticoid therapy is associated with potentially serious adverse events including osteoporosis with bone fracture. The recent development of orally administered leukotriene receptor an...Continue Reading

Citations

Jun 24, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P DevillierC Advenier
May 18, 2012·The Cochrane Database of Systematic Reviews·Bhupendrasinh F Chauhan, Francine M Ducharme
Jan 27, 2006·The Cochrane Database of Systematic Reviews·P SeddonT J Lasserson
Dec 4, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sandra SuessmuthMonika Gappa
Apr 18, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·E G Weinberg, I Naya
Apr 23, 2019·Perspectives in Clinical Research·Jaideep GogtayVaibhav Gaur
Aug 12, 2020·Drug Development Research·Cristiano Colalto

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