Oral Zinc Supplementation Restores Superoxide Radical Scavengers to Normal Levels in Spermatozoa of Iraqi Asthenospermic Patients

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Mahmoud Hussein HadwanAbdul Razzaq S Alsalman

Abstract

Oxidative stress and decreased antioxidant levels have been projected as potential factors involved in the pathophysiology of diverse male infertility types, including asthenospermia. The present study was conducted to examine the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with oxido-sensitive index level (superoxide dismutase/xanthine oxidase ratio) in the seminal plasma of asthenospermic patients. Semen samples were obtained from 60 fertile (age 31.6 ± 3.3 years) and 60 asthenospermic men (age 32.5 ± 3.23 years) from July 2011 to July 2012, from couples who had consulted the infertility clinic of the Babil hospital of maternity (Hillah, Iraq). The subfertile group was treated with zinc sulfate, every participant took 2 capsules (220 mg each) of zinc sulfate per day for 3 months. Semen samples were obtained (before and after zinc sulfate supplementation). Oxido-sensitive index level, catalase-like activity and various sperm parameters were measured. The value of the oxido-sensitive index of fertile controls (1.28 + 0.31 in seminal plasma and 1.57 + 0.62 in spermatozoa) was significantly higher than that of the infertile patient group (0.56 + 0.48 in seminal plasma and 0.65...Continue Reading

Associated Clinical Trials

Citations

Dec 3, 2016·Biological Trace Element Research·Serhan OzyıldırımRasim Mogulkoc
Nov 9, 2018·Expert Opinion on Pharmacotherapy·Ylenia DucaSandro La Vignera
Apr 11, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Edyta Suliga, Stanisław Głuszek
Jan 21, 2020·Reproductive Medicine and Biology·Kazutaka TeraiAkira Tsujimura
Dec 21, 2018·International Journal of Molecular Sciences·Karl KernsPeter Sutovsky
Dec 1, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Akira TsujimuraShigeo Horie
Oct 28, 2021·Reproduction in Domestic Animals = Zuchthygiene·Lluis Ferré-DolcetStefano Romagnoli

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