PMID: 9177242Jun 10, 1997Paper

Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy

Proceedings of the National Academy of Sciences of the United States of America
Theodor KoschinskyHelen Vlassara

Abstract

Endogenous advanced glycation endproducts (AGEs) include chemically crosslinking species (glycotoxins) that contribute to the vascular and renal complications of diabetes mellitus (DM). Renal excretion of the catabolic products of endogenous AGEs is impaired in patients with diabetic or nondiabetic kidney disease (KD). The aim of this study was to examine the oral absorption and renal clearance kinetics of food AGEs in DM with KD and whether circulating diet-derived AGEs contain active glycotoxins. Thirty-eight diabetics (DM) with or without KD and five healthy subjects (NL) received a single meal of egg white (56 g protein), cooked with (AGE-diet) or without fructose (100 g) (CL-diet). Serum and urine samples, collected for 48 hr, were monitored for AGE immunoreactivity by ELISA and for AGE-specific crosslinking reactivity, based on complex formation with 125I-labeled fibronectin. The AGE-diet, but not the CL-diet, produced distinct elevations in serum AGE levels in direct proportion to amount ingested (r = 0.8, P < 0.05): the area under the curve for serum ( approximately 10% of ingested AGE) correlated directly with severity of KD; renal excretion of dietary AGE, although normally incomplete (only approximately 30% of amount...Continue Reading

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Citations

Apr 7, 2000·Diabetes/metabolism Research and Reviews·A Ceriello
Jan 5, 2002·Diabetes/metabolism Research and Reviews·H Vlassara
Jul 12, 2002·Diabetes/metabolism Research and Reviews·Feng ZhengHelen Vlassara
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Feb 7, 2004·Current Diabetes Reports·Melpomeni PeppaHelen Vlassara
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May 26, 2011·Nature Reviews. Endocrinology·Helen Vlassara, Gary E Striker

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