Orally administered brown seaweed-derived β-glucan effectively restrained development of gastric dysplasia in A4gnt KO mice that spontaneously develop gastric adenocarcinoma

International Immunopharmacology
Mark Joseph DesameroShigeru Kyuwa

Abstract

β-Glucan refers to a heterogeneous group of chemically defined storage polysaccharides containing β-(1,3)-d-linked glucose polymers with branches connected by either β-(1,4) or β-(1,6) glycosidic linkage. To date, an extensive amount of scientific evidence supports their multifunctional biological activities, but their potential involvement in the progression of premalignant lesions remains to be clarified. A4gnt KO mice that lack α1,4-N-acetylglucosamine-capped O-glycans in gastric gland mucin are a unique animal model for gastric cancer because the mutant mice spontaneously develop gastric cancer through hyperplasia-dysplasia-adenocarcinoma sequence. In particular, A4gnt KO mice show gastric dysplasia during 10-20 weeks of age. Here we investigated the putative gastro-protective activity of brown seaweed-derived β-glucan (Laminaran) against development of gastric dysplasia, precancerous lesion for gastric cancer in A4gnt KO mice. The mutant mice at 12 weeks of age were randomly assigned into three treatment groups namely, wildtype control + distilled water (normal control), A4gnt KO mice + distilled water (untreated control), and A4gnt KO mice + 100 mg/kg Laminaran. After 3 weeks, the stomach was removed and examined for morp...Continue Reading

Citations

Apr 10, 2019·Journal of Leukocyte Biology·Ce TangYoichiro Iwakura
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Liangjun YangHuafeng Pan
May 6, 2021·International Journal of Molecular Sciences·Mark Joseph Maranan DesameroShigeru Kakuta
Sep 3, 2019·The Science of the Total Environment·Samara Rosolem LimaAna Maria Reis Ferreira

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