PMID: 15362485Sep 15, 2004Paper

Orally administered tryptophan and experimental type 2 diabetes

Molecular and Cellular Biochemistry
M A TormoR Hernández

Abstract

There is a link between diabetes and oxidative stress. Hyperglycaemia leads to free radical generation and alterations of endogenous antioxidants. Our aim is to study the effect of orally administered L-tryptophan (TRP), the melatonin precursor, an endogenous antioxidant, on circulating levels of glycaemia, insulin and melatonin, and on the superoxide dismutase and catalase antioxidant systems in non-diabetic (ND) and type 2 diabetic (n5-STZ) male Wistar rats. At 19:30 every day for 15 days, TRP (125 mg/kg body weight) was administered orally. At 09:00 every two days the glycaemia was measured and every day the intake of food and water was recorded. At the beginning and end of treatment (at 09:00; 21:00; 02:00) plasma insulin and melatonin levels were measured, and (at 09:00) the enzymatic activities of catalase and superoxide dismutase (SOD) in erythrocytes were also measured. Glycaemia values were greater (p < 0.01) in n5-STZ rats than in ND rats, while insulin levels were lower (p < 0.05) at all times studied and these parameters were not altered by the TRP administration. Melatonin levels at 02:00 were lower in n5-STZ than in ND rats (p < 0.05). The TRP administration did not modify the circulating melatonin levels in ND ra...Continue Reading

Citations

Aug 16, 2006·Neuro-degenerative Diseases·Gilles J GuilleminBruce J Brew
Sep 15, 2015·Metabolomics : Official Journal of the Metabolomic Society·Norihide YokoiSusumu Seino
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Debra D CanabalVanessa H Routh
Mar 14, 2007·The British Journal of Nutrition·Erik HöglundOyvind Overli
Nov 19, 2013·Journal of the Science of Food and Agriculture·Maria P MilagresHércia S D Martino
Sep 30, 2016·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Cacio Ricardo WietzycoskiManoel Roberto Maciel Trindade

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