Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.

Bioorganic & Medicinal Chemistry Letters
John E CoughlinRadhakrishnan P Iyer

Abstract

The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).

References

May 25, 2004·Antimicrobial Agents and Chemotherapy·Radhakrishnan P IyerBrent Korba
May 25, 2004·Antimicrobial Agents and Chemotherapy·Radhakrishnan P IyerJohn D Morrey
Jun 12, 2004·Seminars in Liver Disease·Robert P Perrillo

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Citations

Feb 14, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·John E CoughlinRadhakrishnan P Iyer
May 22, 2021·Journal of Medicinal Chemistry·Markéta Pimková PolidarováGabriel Birkuš

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