Abstract
To determine if oral/systemic delivery of baclofen can effectively decrease spastic hypertonia due to acquired brain injury (traumatic brain injury, stroke, anoxia, or encephalopathy). Tertiary care outpatient rehabilitation center directly attached to a university hospital. Patients were a convenience sample recruited consecutively who had been referred for treatment of their spastic hypertonia to our spasticity clinic over a 5-year period. The spastic hypertonia was due to an acquired brain injury by either traumatic brain injury (TBI), stroke, or anoxic brain injury. All patients were more than 6 months postinjury or illness. Retrospective review of patients before and after initiation of treatment with oral baclofen, per standardized clinical data sheets. Thirty-five patients (22 TBI patients) were started on oral baclofen and were reevaluated between 1 to 3 months after initiation of treatment. Data for motor tone (Ashworth scores), spasm scores (Penn spasm frequency score), and deep tendon reflex scores were collected on the affected upper extremity (UE) and lower extremity (LE) side(s). Normal extremities were not assessed. Differences over time were assessed via descriptive statistics and Wilcoxon signed-rank. After 1 t...Continue Reading
References
Oct 1, 1987·Archives of Neurology·R A RudickR L Krall
Oct 1, 1986·Paraplegia·C W Roy, I R Wakefield
Jan 1, 1985·Clinical Neuropharmacology·R Sandyk, M A Gillman
Dec 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·P AshbyE Lightfoot
May 14, 1981·The New England Journal of Medicine·V R Young
Nov 24, 1993·JAMA : the Journal of the American Medical Association·A L AlbrightJ Janosky
Jan 1, 1994·Neurology·C J BrutonC D Frith
Feb 1, 1993·Journal of Neurosurgery·J R CoffeyB Gill
May 1, 1996·Archives of Physical Medicine and Rehabilitation·J M MeythalerM Hadley
Dec 1, 1996·Archives of Neurology·B FordS Fahn
Mar 1, 1997·Spinal Cord·M M PriebeW H Olson
May 1, 1997·Archives of Physical Medicine and Rehabilitation·M E MuellerW H Olson
Sep 1, 1997·Journal of Neurosurgery·J M MeythalerM N Hadley
Jan 23, 1999·Archives of Physical Medicine and Rehabilitation·J M MeythalerM N Hadley
Oct 9, 1999·Neurosurgery·P A GrabbJ M Meythaler
Feb 11, 2000·Archives of Physical Medicine and Rehabilitation·N C CutterG Whiteneck
Aug 4, 2001·Stroke; a Journal of Cerebral Circulation·D A GelberM Richardson
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·J M MeythalerM N Hadley
Sep 12, 2001·Archives of Physical Medicine and Rehabilitation·J M MeythalerR M Brunner
May 9, 2003·Archives of Physical Medicine and Rehabilitation·Jay M MeythalerRobert C Brunner
Citations
Jun 4, 2014·Archives of Physical Medicine and Rehabilitation·Herre W HeetlaTeus van Laar
Apr 25, 2007·Brain Injury : [BI]·Gerard E FranciscoCindy B Ivanhoe
May 11, 2012·Brain Injury : [BI]·Alessandro ClemenziPaola Cicinelli
Mar 17, 2007·Brain Injury : [BI]·Shawn MarshallMark Bayley
Jan 24, 2016·Brain Research·Saurabha BhatnagarRoss Zafonte
Oct 31, 2007·Physical Medicine and Rehabilitation Clinics of North America·Carol Y CrooksKathleen R Bell
Nov 7, 2006·Archives of Physical Medicine and Rehabilitation·Cindy B IvanhoeSamuel P Grissom
Jul 7, 2009·Archives of Physical Medicine and Rehabilitation·Marco SaràStefano Govoni
Mar 20, 2008·Archives of Physical Medicine and Rehabilitation·Steven R FlanaganSunil Kothari
Nov 12, 2016·Seizure : the Journal of the British Epilepsy Association·Christian E ElgerChristian Hoppe
Aug 27, 2016·Clinical Neuropharmacology·Adán Pérez-ArredondoLiliana Carmona-Aparicio
Dec 3, 2014·The Cochrane Database of Systematic Reviews·Melissa J MaguireAnthony G Marson
Sep 14, 2006·The American Journal of Gastroenterology·Mitchell S CappellPhilip O Katz
May 6, 2016·Stroke; a Journal of Cerebral Circulation·Carolee J WinsteinUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Mar 24, 2006·American Journal of Physical Medicine & Rehabilitation·Wayne A GordonTina Chandna
Apr 22, 2016·British Journal of Clinical Pharmacology·H W HeetlaT van Laar
Dec 12, 2019·Spinal Cord·Shingo YoshizakiSeiji Okada
Mar 11, 2020·Frontiers in Neurology·Johannes M N EnslinAnthony Figaji
Oct 11, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Stephy George, Meagan Johns
Jul 23, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Emma E J KasteelAnne Zwartsen
Nov 16, 2010·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Kathleen HardyStephen J Page
Dec 23, 2021·Expert Review of Neurotherapeutics·Jörg Wissel, Songjin Ri