Orally projecting interneurones in the guinea-pig small intestine

The Journal of Physiology
S J BrookesM Costa

Abstract

1. Orally projecting, cholinergic interneurones are important in mediating ascending excitatory reflexes in the small intestine. We have shown that there is just one major class of orally projecting interneurone, which we have characterized using retrograde labelling in organ culture, combined with immunohistochemistry, intracellular recording and dye filling. 2. Orally projecting interneurones, previously shown to be immunoreactive for choline acetyltransferase, tachykinins, enkephalin, calretinin and neurofilament protein triplet, have axons up to 14 mm long and are the only class of cells with orally directed axons more than 8.5 mm long. 3. They are all small Dogiel type I neurones with short dendrites, usually lamellar in form, and a single axon which sometimes bifurcates. Their axons give rise to short varicose collaterals in myenteric ganglia more than 3 mm oral to their cell bodies. 4. Orally projecting interneurones receive prominent fast excitatory post synaptic potentials (fast EPSPs). A major source of fast EPSPs is other ascending interneurones located further aborally. They also receive fast EPSPs from circumferential pathways. 5. In the stretched preparations used in this study, orally projecting interneurones wer...Continue Reading

References

Sep 1, 1979·British Medical Bulletin·G D Hirst
Jul 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·M Costa, J B Furness
Mar 1, 1986·The Journal of Physiology·J F CassellE M McLachlan
Apr 1, 1985·The Journal of Physiology·G D HirstD F van Helden
Jan 1, 1989·British Journal of Pharmacology·J J GalliganT Tokimasa
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
Jun 1, 1984·Journal of Neuroscience Methods·A S Finkel, S Redman
Dec 1, 1982·The Journal of Physiology·R A North, T Tokimasa
Apr 1, 1980·The Journal of Physiology·S M JohnsonR A North
Jun 1, 1995·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J B FurnessJ C Bornstein
Jan 1, 1994·Annual Review of Physiology·A Surprenant
Dec 1, 1993·Current Opinion in Neurobiology·R M Harris-Warrick
Mar 30, 1958·The Japanese Journal of Physiology·T HUKUHARAS NAKAYAMA
Jan 1, 1974·The Journal of Physiology·G D HirstI Spence
May 11, 1899·The Journal of Physiology·W M Bayliss, E H Starling

❮ Previous
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Citations

Jan 9, 2001·The Anatomical Record·S J Brookes
Mar 19, 2005·Histochemistry and Cell Biology·A BrehmerH Rupprecht
Dec 25, 2010·Histochemistry and Cell Biology·Samir JabariAxel Brehmer
Jul 6, 2000·Journal of Neuroscience Methods·E A Thomas
Aug 29, 1998·Journal of the Autonomic Nervous System·M HananiJ H Szurszewski
Jul 25, 2003·Autonomic Neuroscience : Basic & Clinical·Robert J PhillipsTerry L Powley
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christian WinterCarsten A Wagner
Nov 15, 2000·Gut·M CostaG W Hennig
Mar 24, 1999·The Journal of Physiology·S J BrookesC M Humphreys
Nov 29, 2002·The Journal of Physiology·Nick J SpencerTerence K Smith
Sep 29, 2009·Autonomic Neuroscience : Basic & Clinical·Cátia Laranjeira, Vassilis Pachnis
Jan 31, 2007·Neuroscience·K B Neal, J C Bornstein
May 23, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Nurgali
Aug 18, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Viktoria DénesRobert Gábriel
Dec 19, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K B Neal, J C Bornstein
Jul 20, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T J HibberdS J H Brookes
Feb 16, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P O BayguinovT K Smith
May 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S E CarboneD A Wattchow
Jan 12, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G W HennigM Costa
Jan 30, 2014·Clinical and Experimental Pharmacology & Physiology·Jordan D ChambersJoel C Bornstein
Oct 15, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S J BrookesM A Gladman
Jul 11, 1998·The Journal of Comparative Neurology·S J BrookesM Schemann
Dec 4, 2003·The Journal of Comparative Neurology·Kulmira NurgaliJohn B Furness
Feb 13, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Brookes
Aug 18, 2017·Journal of Neural Engineering·Bradley B BarthXiling Shen
Jun 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K J LePardJ J Galligan
Mar 19, 2008·Clinical and Experimental Pharmacology & Physiology·Andrei SibaevMartin Storr
Oct 7, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nick J SpencerTerence K Smith
Aug 26, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Adam HumenickSimon J H Brookes
May 9, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·R BisschopsJ Tack
Jul 15, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hwei L OngGreg J Barritt
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·S Vanner

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