Aug 15, 2014

Orb prevents autophagy in the Drosophila germline through translational repression of Atg12 mRNA

BioRxiv : the Preprint Server for Biology
Isabelle BusseauMartine Simonelig

Abstract

Drosophila Orb, the homologue of vertebrate CPEB is a key translational regulator involved in oocyte polarity and maturation through poly(A) tail elongation of specific mRNAs. orb has also an essential function during early oogenesis which has not been addressed at the molecular level. Here, we show that orb prevents cell death during early stages of oogenesis, thus allowing oogenesis to progress. It does so through the repression of autophagy, by directly repressing, together with the CCR4 deadenylase, the translation of Autophagy-specific gene 12 ( Atg12 ) mRNA. The uncontrolled autophagy observed in orb mutant ovaries is reduced when Atg12 mRNA levels are decreased. These results reveal a role of Orb in translational repression and identify autophagy as an essential pathway regulated by Orb during early oogenesis. Importantly, they also establish translational regulation as a major mode of control of autophagy, a key process in cell homeostasis in response to environmental cues.

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Mentioned in this Paper

Vertebrates
CPEB1 gene
Biochemical Pathway
Atg12
Autophagy-Related Protein 12
MRNA Maturation
Cell Polarity
CPEB1
Both Ovaries
CCRN4L gene

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