PMID: 2487225Jan 1, 1989Paper

Orbital aspergillosis. Conservative debridement and local amphotericin irrigation

Ophthalmic Plastic and Reconstructive Surgery
G J Harris, B R Will

Abstract

A patient maintained on long-term immunosuppressive agents after bone marrow transplantation developed an Aspergillus abscess in the right orbit. The abscess was resected without visual compromise and the orbit was irrigated regularly with amphotericin B via an indwelling catheter. Follow-up computed tomography, surgical exploration, and histological analysis demonstrated suppression of fungal growth in the orbit. Persistent fungus was recovered from nonirrigated sinuses despite their previous surgical evacuation and continued systemic amphotericin B administration. Treatment of orbital aspergillosis should include surgical reduction of the local fungal inoculum, supplementation of intravenous antifungal agents with local delivery to minimize systemic toxicity, and attempts to reverse the immunosuppression. If the last is not possible, extensive extirpation of normal surrounding tissues will not prevent repopulation by the ubiquitous fungus.

Citations

Sep 1, 1996·Survey of Ophthalmology·L A LevinA S Baker
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A StevensG A Pankey
Jan 1, 2012·Medical Mycology Case Reports·Arzu Taskiran ComezMuserref Tatman Otkun
Sep 1, 1996·Ophthalmology·G G MassryW Harrison
Dec 24, 1997·Ophthalmology·S R KlapperE L Alford
Dec 7, 2007·American Journal of Otolaryngology·Naresh K PandaArunaloke Chakrabarti
Oct 28, 2011·Orbit·Norman Mainville, David R Jordan
Oct 22, 2016·Ophthalmic Plastic and Reconstructive Surgery·Kristin E HirabayashiM Reza Vagefi
Oct 1, 1996·Cancer·T al-TweigeriJ R Mackey
Oct 22, 2016·Ophthalmic Plastic and Reconstructive Surgery·Dnyaneshwar D AthavaleNigel Biggs
May 29, 2004·Ophthalmic Plastic and Reconstructive Surgery·Melanie L McCartyRaul C Ribeiro
Apr 24, 2007·International Ophthalmology Clinics·James Kirszrot, Peter A D Rubin
Mar 21, 2015·Ophthalmic Plastic and Reconstructive Surgery·Zachary P Joos, Bhupendra C K Patel
May 16, 2017·Current Opinion in Ophthalmology·Evan Kalin-HajduRobert C Kersten
Jan 5, 2002·Ophthalmic Plastic and Reconstructive Surgery·S UgurluN Yulug
Mar 21, 2019·Ophthalmic Plastic and Reconstructive Surgery·Kristin E HirabayashiM Reza Vagefi
Aug 3, 2001·Cancer Control : Journal of the Moffitt Cancer Center·A TallamrajuR L Sandin
Apr 7, 2007·Journal of Pediatric Ophthalmology and Strabismus·Viyay B WaghS M Betharia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.