Orbital burkitt lymphoma in immunocompetent patients: a report of 3 cases and a review of the literature

Ophthalmic Plastic and Reconstructive Surgery
Paul S BakerJames A Katowitz

Abstract

To describe a series of 3 immunocompetent patients with the sporadic form of orbital Burkitt lymphoma and review the outcomes of such patients reported in the scientific literature. Retrospective review of medical records and the literature. Cases of orbital Burkitt lymphoma in immunocompromised and African patients were excluded from the review. Measured parameters included gender, age, ocular signs, imaging results, the range of systemic involvement, and treatment. Current cases and review of the scientific literature resulted in 16 immunocompetent patients with sporadic orbital Burkitt lymphoma. The median age at presentation was 12 years. Most common ocular signs at presentation were proptosis (13/16), external ophthalmoplegia (9/16), and eyelid edema (7/16). Optic neuropathy was noted in 5 of 16 patients. Concomitant paranasal sinus involvement was present in 8 of 16 patients. Fourteen (88%) of the patients had systemic involvement, of which the most common locations were central nervous system (6/16), lymphatics (6/16), bone marrow (6/16), and liver (4/16). Survival data were available for 13 patients. Seven patients (54%) died within 12 months of presentation. Sporadic orbital Burkitt lymphoma occurs in immunocompetent i...Continue Reading

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Citations

Sep 10, 2014·BMC Ophthalmology·Chichua AlexanderPavlidis Mitrofanis
May 17, 2018·Journal of Medical Case Reports·Brice N VofoLeopold N Aminde
Mar 2, 2021·The Journal of Craniofacial Surgery·Luiz Henrique Soares TorresValfrido Antônio Pererira Filho

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