Orbital carcinomas treated with adjuvant intensity-modulated radiation therapy

Head & Neck
Randa TaoJack Phan

Abstract

The purpose of this study was to assess outcomes of patients with orbital carcinomas treated with orbital exenteration and intensity-modulated radiation therapy (IMRT). Twenty-nine patients were treated with orbital exenteration and postoperative IMRT between 2002 through 2011; their medical records were retrospectively reviewed. Adenoid cystic carcinoma represented the most common histology (41%) followed by squamous cell carcinoma (21%). Perineural invasion (PNI) was identified in 22 patients (76%). The median radiation dose was 60 Gy (range, 60-70). Seven patients (24%) received neck radiation. The median follow-up was 43 months (range, 5-102 months). Five-year local control, overall survival (OS), and disease-free survival rates were 83%, 60%, and 55%, respectively. PNI (p = .01) and especially involvement of a named nerve (p = .001) significantly correlated with worse OS. Favorable disease control rates for orbital carcinomas are achievable with IMRT after orbital exenteration even for patients with advanced disease. Toxicity for the contralateral eye was minimal. © 2015 Wiley Periodicals, Inc. Head Neck 38: E580-E587, 2016.

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Citations

Oct 12, 2015·International Journal of Radiation Oncology, Biology, Physics·Emma B HollidaySteven J Frank
Jun 9, 2016·Current Opinion in Ophthalmology·Kyung In WooBita Esmaeli
Apr 12, 2017·Asia-Pacific Journal of Ophthalmology·Simon AndreasenSteffen Heegaard
Mar 9, 2018·International Ophthalmology Clinics·Alan D ProiaJulie A Woodward

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