Abstract
The purpose of this study was to assess outcomes of patients with orbital carcinomas treated with orbital exenteration and intensity-modulated radiation therapy (IMRT). Twenty-nine patients were treated with orbital exenteration and postoperative IMRT between 2002 through 2011; their medical records were retrospectively reviewed. Adenoid cystic carcinoma represented the most common histology (41%) followed by squamous cell carcinoma (21%). Perineural invasion (PNI) was identified in 22 patients (76%). The median radiation dose was 60 Gy (range, 60-70). Seven patients (24%) received neck radiation. The median follow-up was 43 months (range, 5-102 months). Five-year local control, overall survival (OS), and disease-free survival rates were 83%, 60%, and 55%, respectively. PNI (p = .01) and especially involvement of a named nerve (p = .001) significantly correlated with worse OS. Favorable disease control rates for orbital carcinomas are achievable with IMRT after orbital exenteration even for patients with advanced disease. Toxicity for the contralateral eye was minimal. © 2015 Wiley Periodicals, Inc. Head Neck 38: E580-E587, 2016.
References
Feb 1, 1975·The Australian and New Zealand Journal of Surgery·P B DasS John
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·R J AmdurR R Million
Apr 1, 1984·International Journal of Radiation Oncology, Biology, Physics·P J FitzpatrickD G Payne
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·L J PetersR A Frankenthaler
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·P SchliengerJ R Vilcoq
Jan 27, 1998·Ophthalmology·C E Margo, Z D Mulla
Sep 23, 1998·Head & Neck·J S CooperM Al-Sarraf
Apr 25, 2003·Ophthalmic Research·Muge AkmansuOzgur Gurel
Jun 12, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·M J KrasinT E Merchant
Oct 7, 2004·Ophthalmology·Misha FaustinaBita Esmaeli
Jul 25, 2006·Radiation Oncology·Stephanie E CombsChristoph Thilmann
Oct 30, 2007·Cancer·Janjira PetsuksiriBita Esmaeli
Nov 27, 2008·Ophthalmic Plastic and Reconstructive Surgery·Adam HsuBita Esmaeli
Jan 10, 2009·Radiation Medicine·Sharad GoyalNing J Yue
Jun 23, 2009·International Journal of Radiation Oncology, Biology, Physics·Avraham EisbruchK Kian Ang
Aug 18, 2009·Survey of Ophthalmology·Paul T Finger
Jun 22, 2010·Cancer·B Ashleigh GuadagnoloXianglin L Du
Jan 18, 2011·The Lancet Oncology·Christopher M NuttingUNKNOWN PARSPORT trial management group
Jun 10, 2011·Cancer·Heath D SkinnerSteven J Frank
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Min Rex Cheung
Citations
Mar 19, 2016·Disability and Rehabilitation·Maura Mitrushina, Robert Tomaszewski
Oct 12, 2015·International Journal of Radiation Oncology, Biology, Physics·Emma B HollidaySteven J Frank
Jun 9, 2016·Current Opinion in Ophthalmology·Kyung In WooBita Esmaeli
Mar 22, 2018·Oncotarget·Kazuhiko HayashiTadashi Kamada
Apr 12, 2017·Asia-Pacific Journal of Ophthalmology·Simon AndreasenSteffen Heegaard
Aug 8, 2019·BMC Cancer·Weixu HuJiade J Lu
Mar 9, 2018·International Ophthalmology Clinics·Alan D ProiaJulie A Woodward
Mar 25, 2021·Cancer Management and Research·Peng XuJinyi Lang