Orbital cellulitis, panophthalmitis, and ecthyma gangrenosum in an immunocompromised host with pseudomonas septicemia

American Journal of Ophthalmology
Luke J MaccheronPeter S Beckingsale

Abstract

To describe a case of Pseudomonas aeruginosa septicemia complicated by orbital cellulitis, panophthalmitis, and ecthyma gangrenosum. Observational case report. An immunosuppressed 62-year-old man developed an unusual skin rash and a painful, swollen right eye with decreased vision. He had myelodysplastic syndrome and P. aeruginosa septicemia. The skin rash manifested as ecthyma gangrenosum. Metastatic orbital cellulitis and panophthalmitis was diagnosed. Despite intravitreal and topical gentamicin, the patient eventually required enucleation. This case represents a rare combination of events: an immunocompromised man developed pneumonia, P. aeruginosa septicemia, and endogenous seeding of the Pseudomonas to the skin, orbit, and eye. Early recognition of endogenous ophthalmic disease is imperative. The prognosis of combined orbital cellulitis and panophthalmitis is poor.

References

Dec 1, 1977·Archives of Ophthalmology·K F YabbaraR M Matossian
Aug 15, 1989·American Journal of Ophthalmology·A HornblassS Ahn-Lee
Feb 1, 1995·Burns : Journal of the International Society for Burn Injuries·M L Jain, A K Garg

Citations

Nov 5, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Andrew Rosser, Deborah E Modha
Apr 7, 2010·Journal of Cataract and Refractive Surgery·Christian DecockElisabeth H Van Aken
Dec 15, 2015·Indian Journal of Ophthalmology·S Praveen KumarArjun Ashokan
Nov 1, 2016·Japanese Journal of Infectious Diseases·Simranjeet AulakhChhaya A Shinde
Dec 17, 2008·Orbit·Panitee LuemsamranPrija Mekanandha
Nov 23, 2006·Ophthalmic Plastic and Reconstructive Surgery·Faris R Ghosheh, Sajeev S Kathuria
Jun 1, 2005·Pediatric Blood & Cancer·Aaron M MilstoneMeghan A Higman
Dec 10, 2013·Ophthalmic Plastic and Reconstructive Surgery·H Joon KimTed H Wojno
Dec 26, 2009·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Kei Suzuki, Takao Sekine
May 31, 2007·European Journal of Ophthalmology·D Diaz-ValleJ Garcia-Sanchez

Related Concepts

Phlegmon
Ecthyma
Orbit (Eye Disorders)
Panophthalmitis
Pseudomonas Infections
Tomography, X-Ray Computerized Axial
Vitreous Body Structure
Eye Enucleation Procedure
Bacteremia
Immunocompromised Host

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