PMID: 7522545Jul 1, 1994Paper

Orbital exenteration in 95 cases of primary conjunctival malignant melanoma

The British Journal of Ophthalmology
A D ParidaensJ L Hungerford

Abstract

The role of orbital exenteration in the management of malignant melanoma of the conjunctiva has been underexplored. The outcome in 95 patients with this condition, who underwent exenteration as a primary treatment (n = 36) or after failure of other treatment (n = 59) for early to advanced stages of the disease, was evaluated. The majority of treated cases had multicentric melanomas sited at prognostically unfavourable locations. In the group of tumours with a maximum thickness of 1.0 mm no melanoma related mortality was noted. Melanomas thicker than 1.0 mm were associated with a mortality varying between 33% and 50%, independent of whether exenteration was performed as primary or secondary treatment. An especially poor outcome was noted for the group of caruncular melanomas despite exenteration. These findings indicate that total eradication of tumour should be performed at an early stage. For this purpose, a combination of debulking surgery and adjunctive cryotherapy or beta radiotherapy is more appropriate than orbital exenteration which causes disfigurement and blindness. Exenteration of the orbit should be reserved as a palliative procedure for advanced stages of neoplastic disease.

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Citations

Jun 9, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Madhavi Kurli, Paul T Finger
Sep 1, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Henrike WuestemeyerGerasimos Anastassiou
Aug 31, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Teresa SandinhaFiona Roberts
Mar 29, 2001·Survey of Ophthalmology·M W WilsonB G Haik
Mar 11, 1998·Survey of Ophthalmology·S Seregard
Jun 7, 2008·Eye·B Damato, S E Coupland
Feb 27, 2003·Cornea·Teresa Rodríguez-AresCarmen Capeans
Aug 26, 1998·The British Journal of Ophthalmology·P T FingerS Liarikos
Jan 30, 2002·The British Journal of Ophthalmology·Gerasimos AnastassiouKlaus-Peter Steuhl
Aug 12, 2009·Clinical Ophthalmology·Jonathan W Kim, David H Abramson
Mar 22, 2013·Clinical Ophthalmology·Li-Anne LimR Max Conway
Mar 23, 2011·Future Oncology·Hooman HarooniArun D Singh
Jan 26, 2010·Journal français d'ophtalmologie·C Levy-Gabriel
Apr 17, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Reza S NassabDouglas Murray
Nov 25, 2006·Ophthalmology·Vanessa LimawararutDinesh Selva
Sep 8, 2004·Ophthalmology·Carol L ShieldsJerry A Shields
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Jan 18, 2015·The British Journal of Ophthalmology·Xinan ShengJun Guo
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Nov 30, 2016·International Ophthalmology Clinics·Jeanie LingSahar Kohanim
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Jan 4, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rita Pinto-ProençaRui Proença
Mar 12, 2002·Clinical & Experimental Ophthalmology·Christopher Layton, William Glasson
Aug 28, 2017·The British Journal of Ophthalmology·Ze ZhangAlejandra Valenzuela
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Jul 2, 2005·Korean Journal of Ophthalmology : KJO·Jungbum ChoiSang Yeul Lee
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Mar 29, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Simone L ScholzWolfgang Sauerwein
Sep 19, 2009·Expert Review of Anticancer Therapy·Bertil Damato, Sarah E Coupland
Jan 13, 2015·Expert Review of Ophthalmology·James R WongCarol L Karp
Nov 7, 2019·International Journal of Molecular Sciences·Ernesto RossiGiampaolo Tortora
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Aug 5, 2020·Acta Ophthalmologica·Lauge Hjorth Mikkelsen

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