Orbital fat regeneration following hormonal treatment of metastatic breast carcinoma

Orbit
Ramzi M AlameddineDon O Kikkawa

Abstract

Enophthalmos in the setting of breast cancer metastatic to the orbit results primarily from the disease pathogenesis, or secondary to treatment effects. Orbital volume restoration and fat regeneration following endocrine treatment monotherapy has not been previously reported. A 76- year-old previously healthy female presented with progressive right enophthalmos secondary to metastatic lobular breast carcinoma. Treatment with an aromatase inhibitor (letrozole) resulted in tumor regression and orbital fat restoration with a corresponding improvement in orbital volume and enophthalmos on clinical exam. The patient is alive on continued letrozole with no progressive disease ten years after diagnosis. This case illustrates the resilience of orbital soft tissues and ability of orbital fat to regenerate in face of breast cancer metastasis. We hypothesize that endocrine monotherapy, and avoidance of radiation therapy, allowed for differentiation of remaining orbital stem cells, and facilitated the fat regenerative process.

References

Jul 1, 1990·Survey of Ophthalmology·R A GoldbergR A Cline
Jan 1, 1987·Ophthalmic Plastic and Reconstructive Surgery·M A StefanyszynJ C Flanagan
Jan 1, 1997·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·A SaitohN Tsuda
Oct 20, 2001·Ophthalmic Plastic and Reconstructive Surgery·J A ShieldsR C Eagle
Mar 23, 2002·Ophthalmic Plastic and Reconstructive Surgery·Diana ReevesRichard Lash
Jul 30, 2005·Ophthalmic Plastic and Reconstructive Surgery·Allan C P GonçalvesMário L R Monteiro
Aug 19, 2007·Current Opinion in Ophthalmology·S Mehdi Ahmad, Bita Esmaeli
Nov 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emad A RakhaIan O Ellis
Mar 11, 2009·Ophthalmic Plastic and Reconstructive Surgery·Bobby S KornKevin C Hicok
Oct 21, 2009·Orbit·Alejandra A ValenzuelaTimothy J Sullivan
Nov 28, 2009·Nature Reviews. Clinical Oncology·Britta Weigelt, Jorge S Reis-Filho
Mar 6, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Elena Novitskaya, Cornelius Rene
Oct 31, 2014·Cancer Medicine·Mieke RaapMatthias Christgen

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Citations

Oct 24, 2019·Breast Disease·Ismini Michail TsagkarakiElias Alexandros Kotteas

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