PMID: 9436742Jan 22, 1998Paper

Orbital high resolution magnetic resonance imaging with fast spin echo in the acute stage of Leber's hereditary optic neuropathy

Journal of Neurology, Neurosurgery, and Psychiatry
Y MashimaY Oguchi

Abstract

Some evidence suggests that the primary locus of the lesion in Leber's hereditary optic neuropathy (LHON) may be intraocular rather than retrobulbar. To clarify this issue, the condition of the retrobulbar portion of the optic nerve was evaluated in patients with the acute stage of LHON. High resolution MRI with fast spin echo sequences of the optic nerve complex in the orbit was carried out. Five patients with acute stage LHON were compared with seven patients with acute stage optic neuritis. On T2 weighted fast spin echo MRI, signal changes did not appear in the retrobulbar optic nerve complex in acute stage LHON. By comparison, patients with optic neuritis showed pronounced high signals in the optic nerve. Subsequent orbital MRI in the atrophic stages of the same patients with LHON showed an increase in signal intensity in the optic nerve toward the orbital apex in both eyes. The present results support the hypothesis that a primary lesion in LHON may be intraocular.

Citations

Jan 24, 2006·Investigative Radiology·Matthias WeigelThorsten Alexander Bley
Dec 16, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Danielle van WestenGunnel Bynke
Feb 15, 2011·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Nancy J Newman
Nov 13, 2008·Journal of Medical Genetics·P Yu-Wai-ManP F Chinnery
Mar 19, 2002·Journal of Medical Genetics·P Yu-Wai-ManP F Chinnery
Oct 25, 2011·Rinshō shinkeigaku = Clinical neurology·Shintaro Hayashi, Koichi Okamoto
Jul 11, 2006·Progress in Retinal and Eye Research·May-Yung YenYau-Huei Wei
Jan 11, 2007·Survey of Ophthalmology·Michael S VaphiadesDavid M Mills
May 29, 2012·Journal français d'ophtalmologie·S BouomraniM Béji
Mar 5, 2003·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Figen BatioğluTeksin Eryilmaz
Jan 5, 2018·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Christelle BlancCatherine Vignal-Clermont
Nov 10, 2004·Eye·N J Newman, V Biousse
Feb 10, 2000·Journal of Computer Assisted Tomography·P M RobitailleA Kangarlu
Dec 9, 2016·Neuro-ophthalmology·Supanut ApinyawasisukAnthony C Arnold
Feb 12, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Shilei CuiXiaojun Zhang
Nov 3, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Fabrício Guimarães GonçalvesArastoo Vossough

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