Orbital mycoses in a pediatric subtropical population: a case series.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Allister S Lee, T J Sullivan

Abstract

To report our experience in the diagnosis and management of invasive fungal infections with orbital involvement in children from a subtropical population. The medical records of children (<18 years of age) with orbital mycosis and treated by the senior author (TJS) from 1995 to 2017 in multiple pediatric tertiary centers were reviewed retrospectively. Six patients (aged 12 weeks to 15 years) were included in this series. Four patients had confirmed infection with isolated pathogens, including mucormycosis (3) and Exserohilum (2). One patient rapidly deteriorated and died before biopsy could be performed; however, the patient was presumed to have invasive fungal disease. Four patients had underlying hematological malignancy, and 1 presented in diabetic ketoacidosis. Orbital apex syndrome was observed in one patient. All patients received liposomal amphotericin B and five underwent at least one debridement surgery. One patient proceeded to orbital exenteration and survived. The overall survival rate was 67%. Orbital mycoses can affect children of all ages. Immunocompromised patients are particularly at risk, and mortality rates are high. In a subtropical population, these infections may be caused by a different spectrum of fungi ...Continue Reading

References

Nov 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B SahinB Hazar
Feb 24, 2001·Ophthalmic Plastic and Reconstructive Surgery·R W PeltonK Davis
Oct 15, 2003·Clinical Microbiology Reviews·Philip A Thomas
May 29, 2004·Ophthalmic Plastic and Reconstructive Surgery·Melanie L McCartyRaul C Ribeiro
Jun 22, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B V JohnDimitrios P Kontoyiannis
Jul 16, 2005·Clinical Microbiology Reviews·Brad SpellbergAshraf Ibrahim
Mar 3, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A AdlerI Levy
Apr 7, 2007·Journal of Pediatric Ophthalmology and Strabismus·Viyay B WaghS M Betharia
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwNational Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Jul 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Georgios ChamilosDimitrios P Kontoyiannis
Mar 1, 2008·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Vivek Sasindran Senthil
Jan 8, 2014·Infection & chemotherapy·Hyo-Lim HongSang-Oh Lee
Apr 1, 2014·Medical Mycology·Aspasia KatragkouEmmanuel Roilides
Aug 16, 2014·Ophthalmic Plastic and Reconstructive Surgery·Brett W DaviesVikram D Durairaj
Mar 21, 2015·Ophthalmic Plastic and Reconstructive Surgery·Zachary P Joos, Bhupendra C K Patel
Oct 22, 2016·Ophthalmic Plastic and Reconstructive Surgery·Dnyaneshwar D AthavaleNigel Biggs
Nov 12, 2016·BMC Infectious Diseases·Zoi Dorothea PanaCollaborators of Zygomyco.net and/or FungiScope™ Registries*
May 16, 2017·Current Opinion in Ophthalmology·Evan Kalin-HajduRobert C Kersten
Nov 7, 2017·International Journal of Pediatric Otorhinolaryngology·Curtis HanbaAdam J Folbe

Related Concepts

amphotericin B lipid complex
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