Abstract
To describe two cases of orbital plasmablastic lymphoma (PBL), a recently defined aggressive large-cell lymphoma with a plasmacytic immunophenotype, typically occurring in the oral cavity of HIV+ patients. To compare their presentation, management, immunohistochemistry and prognosis with orbital diffuse large B-cell lymphoma (DLBCL). Consecutive, comparative case series of patients presenting to a specialist orbital service with histologically proven PBL or DLBCL. Two cases of PBL and 14 cases of DLBCL were identified. The former were 40-49-year-old men, one HIV+, presenting with marked orbital/sinonasal tumour without oral involvement. Both tumours were negative for B-cell markers (CD20, CD79a), showed a plasmacytic immunophenotype (positive for CD 138, Vs38c), and displayed a Ki67 index of 100%. Despite chemotherapy, both patients died within 1 year. Of the 14 patients with DLBCL, 57% were female, mean age 65 yrs, and none were immunocompromised. Only 7 (50%) had sinus involvement and 3 (21%) had prior systemic lymphoma. All were positive for B-cell markers, with a Ki67 index of 55%-80%. None died within 1 year of diagnosis. PBL can present in the orbit and is more aggressive than DLBCL. It must be considered in the different...Continue Reading
References
Jul 25, 2000·The British Journal of Ophthalmology·C JenkinsA Norton
Feb 15, 2001·Archives of Pathology & Laboratory Medicine·Y LinM A Vasef
Mar 2, 2002·European Journal of Haematology·T RobakK Warzocha
Mar 16, 2002·Blood·Eric OksenhendlerVéronique Meignin
Mar 1, 2003·Blood·Richard F LittleWyndham H Wilson
Jun 5, 2003·Annals of Hematology·D D NguyenR H Advani
Jun 6, 2003·Histopathology·R ChettyK Gatter
Nov 18, 2003·The British Journal of Dermatology·I NicolM A Richard
May 1, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·P HäusermannS A Buechner
May 29, 2004·The American Journal of Surgical Pathology·Lluís ColomoElías Campo
Oct 21, 2004·American Journal of Hematology·Steven A SchichmanPaulette Mehta
Jan 20, 2005·Histopathology·L B JordanJ R Goodlad
Jan 22, 2005·Journal of Cutaneous Pathology·Shannon VermaCynthia M Magro
Jun 29, 2005·Annales de pathologie·Jean-Philippe DalesColette Taranger-Charpin
Jul 23, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Mark A ScheperJohn J Sauk
Dec 6, 2005·The American Journal of Surgical Pathology·Henry Y DongNancy L Harris
Aug 30, 2006·Human Pathology·Fabio TavoraX Frank Zhao
Jun 24, 2008·Orbit·Alejandra A ValenzuelaTimothy J Sullivan
Jul 4, 2008·Oral and Maxillofacial Surgery·Richard BarkhuysenStefaan J Bergé
Aug 30, 2008·American Journal of Hematology·Antonino Carbone, Annunziata Gloghini
Citations
Jun 1, 2010·Head and Neck Pathology·Justin A Bishop, William H Westra
Dec 14, 2011·American Journal of Clinical Oncology·Robert M SchwarczPaul T Finger
May 25, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Eun Joo ParkKwang Joong Kim
Dec 29, 2012·Clinical Ophthalmology·Kaustubh MulaySantosh G Honavar
Jan 1, 2011·Journal of Radiology Case Reports·Andrew J Degnan, Lucien M Levy
Oct 17, 2015·Seminars in Diagnostic Pathology·Genevieve M Crane, Amy S Duffield
Apr 17, 2012·American Journal of Ophthalmology·Rebecca C StacyHans E Grossniklaus
Apr 1, 2012·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Hind M AlkatanAyman Al-Ayoubi
Jan 18, 2011·Annals of Diagnostic Pathology·Jennifer Chapman-FredricksOffiong Ikpatt
Dec 7, 2018·JAMA Ophthalmology·Angela Y Zhu, Roomasa Channa
Jan 22, 2020·Ocular Immunology and Inflammation·Lynn K Gordon, Helen Danesh-Meyer
Feb 15, 2020·Ocular Immunology and Inflammation·David Meyer, Derrick P Smit
Jan 30, 2018·Clinical Case Reports·Edward Bloch, Fiona Robinson
Sep 21, 2017·Case Reports in Pathology·Carolline Fontes Alves MarianoFernando Chahud
Nov 14, 2018·Case Reports in Ophthalmological Medicine·A MoramarcoA Lambiase