Orbital Radiation Therapy in Thyroid Eye Disease

Ophthalmic Plastic and Reconstructive Surgery
Rao V ChunduryJulian D Perry

Abstract

To review the current literature summarizing the state of knowledge on the use of orbital radiation therapy (ORT) in thyroid eye disease. A systematic review and analysis of the literature were performed. MEDLINE/PubMed, Cochrane Library databases, SCOPUS, and recent relevant journal articles were searched. Thyroid eye disease is an autoimmune disorder that has the propensity to affect multiple orbital tissues and can cause permanent vision loss. In moderate to severe disease, treatment may be warranted and can include multiple therapeutic modalities. Orbital radiation therapy is frequently used in this setting and may act to break the inflammatory cycle of glycosaminoglycan production and deposition. There has been a wealth of data regarding the effectiveness of ORT in thyroid eye disease resulting in the publication of treatment algorithms and management guidelines; however, there continues to be a lack of conformity among experts on the exact role of ORT in thyroid eye disease. The multiple different thyroid eye disease classification schemes and the concurrent use of other therapeutic modalities challenge the interpretation of studies evaluating the effectiveness of thyroid eye disease. Despite these limitations, the curren...Continue Reading

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Citations

Jul 21, 2020·Seminars in Ophthalmology·Victor D Liou, Michael K Yoon
Aug 5, 2017·Expert Review of Ophthalmology·Alexander D BlandfordJulian D Perry
May 6, 2021·Journal of the Endocrine Society·Chrysoula Dosiou, Andrea Lora Kossler
Jul 16, 2021·Therapeutic Advances in Ophthalmology·Clara J MenSara T Wester

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