Orbitofrontal connectivity is associated with depression and anxiety in marijuana-using adolescents.

Journal of Affective Disorders
Punitha SubramaniamDeborah Yurgelun-Todd

Abstract

Prevalence of marijuana (MJ) use among adolescents has been on the rise. MJ use has been reported to impact several brain regions, including frontal regions such as the orbitofrontal cortex (OFC). The OFC is involved in emotion regulation and processing and has been associated with symptoms of depression and anxiety. Therefore, we hypothesized that adolescent MJ users would show disruptions in OFC connectivity compared with healthy adolescents (HC) which would be associated with symptoms of mood and anxiety. 43 MJ-using and 31 HC adolescents completed clinical measures including the Hamilton Anxiety Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D). Resting-state functional magnetic resonance imaging data was also acquired for all participants. In MJ users, increased depressive symptoms were associated with increased connectivity between the left OFC and left parietal regions. In contrast, lower ratings of anxiety were associated with increased connectivity between right and left OFC and right occipital and temporal regions. These findings indicate significant differences in OFC connectivity in MJ-using adolescents, which correlated with mood/anxiety. Future studies with an increased number of female participants is re...Continue Reading

Citations

Jul 18, 2019·Journal of Dual Diagnosis·Yann ChyeMurat Yücel
May 19, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Zinaida I StorozhevaAnna V Kirenskaya
Aug 28, 2020·Frontiers in Human Neuroscience·Shahnaza HamidullahJibran Y Khokhar
Mar 30, 2021·Current Addiction Reports·Punitha Subramaniam, Deborah Yurgelun-Todd
Jan 4, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Liangsuo MaF Gerard Moeller
Aug 28, 2020·Behavioural Brain Research·Chandni ShethDeborah Yurgelun-Todd

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