Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability

Cerebral Cortex
David M ColeJohn D Beaver

Abstract

Animal research and human postmortem evidence highlight the importance of brain dopamine D3 receptor (D3R) function in multiple neuropsychiatric disorders, including addiction. Separate anatomical and functional neuroimaging findings implicate disrupted frontal cortical connectivity with distributed brain networks in processes relevant for these diseases. This potential conjunction between molecular and functional markers has not, however, been tested directly. Here, we used a novel combination of [(11)C]-(+)-PHNO positron emission tomography and resting-state functional magnetic resonance imaging in the same healthy individuals to investigate whether differences in midbrain D3R availability are associated with functional interactions between large-scale networks and regions involved in reward processing and cognition. High midbrain D3R availability was associated with reduced functional connectivity between orbitofrontal cortex (OFC) and networks implicated in cognitive control and salience processing. The opposite pattern was observed in subcortical reward circuitry and the "default mode" network, which showed greater connectivity with OFC in individuals with high D3R availability. These findings demonstrate that differential...Continue Reading

References

Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·E A NimchinskyP R Hof
Mar 24, 2000·Cerebral Cortex·A BecharaA R Damasio
Jan 3, 2001·Nature Neuroscience·J O'DohertyC Andrews
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GusnardM E Raichle
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Oct 18, 2002·Neuron·Wolfram Schultz
Dec 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kevin J BlackJoel S Perlmutter
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Feb 18, 2004·IEEE Transactions on Medical Imaging·Christian F Beckmann, Stephen M Smith
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia IzquierdoElisabeth A Murray
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Jul 9, 2005·Trends in Cognitive Sciences·John M AllmanAtiya Y Hakeem
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christian F BeckmannStephen M Smith
Sep 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia IzquierdoElisabeth A Murray
Apr 15, 2006·CNS & Neurological Disorders Drug Targets·P SokoloffC Gross
Oct 31, 2006·Trends in Molecular Medicine·Ruben D Baler, Nora D Volkow
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Apr 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthäus WilleitShitij Kapur
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David H ZaldRobert M Kessler
Apr 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nicola FilippiniClare E Mackay
Apr 21, 2009·Neuron·William W SeeleyMichael D Greicius
Jun 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clare KellyKatie McMahon
Jun 10, 2009·Human Brain Mapping·Vesa KiviniemiOsmo Tervonen
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithChristian F Beckmann
Aug 14, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susan R Sesack, Anthony A Grace
Aug 22, 2009·Behavioural Pharmacology·Marcel M van GaalenGerhard Gross

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Citations

Jun 25, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Shinichiro NakajimaAriel Graff-Guerrero
Jan 9, 2013·Brain Connectivity·Chandan J Vaidya, Evan M Gordon
Sep 4, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Doris PayerIsabelle Boileau
May 27, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giacomo KochAlessandro Martorana
Aug 25, 2015·Parkinsonism & Related Disorders·I Aracil-Bolaños, A P Strafella
May 15, 2015·Journal of Neural Transmission·Nasim VousooghiMohammad Reza Zarrindast
Aug 25, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Emilio Merlo Pich, Ginetta Collo
Jul 5, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Isabelle BoileauDoris Payer
Dec 3, 2014·Neurobiology of Aging·Nicolien M van der KolkBart P van de Warrenburg
Jun 11, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shinichiro NakajimaAriel Graff-Guerrero
Jul 27, 2014·Neurobiology of Aging·Francesca TrojsiGioacchino Tedeschi
Sep 8, 2016·The European Journal of Neuroscience·Pierre Sokoloff, Bernard Le Foll
Oct 25, 2017·Metabolic Brain Disease·Fleur L WartonErnesta M Meintjes
Oct 30, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer A HadleyAdrienne C Lahti
Aug 8, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Doris E PayerIsabelle Boileau
Jul 13, 2017·Synapse·Atsuko Nagano-SaitoChawki Benkelfat
Jan 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rui YuanVinod Menon
Feb 19, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Paula TrujilloDaniel O Claassen

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