Orbitofrontal disinhibition of pain in migraine with aura: an interictal EEG-mapping study

Cephalalgia : an International Journal of Headache
Rina LevDavid Yarnitsky

Abstract

This study aimed to identify the cortical mechanisms underlying the processes of interictal dishabituation to experimental pain in subjects suffering from migraine with aura (MWA). In 21 subjects with MWA and 22 healthy controls, cortical responses to two successive trials of noxious contact-heat stimuli were analyzed using EEG-tomography software. When compared with controls, MWA patients showed significantly increased pain-evoked potential amplitudes accompanied by reduced activity in the orbitofrontal cortex (OFC) and increased activity in the pain matrix regions, including the primary somatosensory cortex (SI) (p < .05). Similarly to controls, MWA subjects displayed an inverse correlation between the OFC and SI activities, and positive interrelations between other pain-specific regions. The activity changes in the OFC negatively correlated with lifetime headache duration and longevity (p < .05). Reduced inhibitory functioning of the prefrontal cortex is a possible cause for disinhibition of the pain-related sensory cortices in migraine. The finding of OFC hypofunction over the disease course is in keeping with current concepts of migraine as a progressive brain disorder.

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Citations

Jan 8, 2013·Current Rheumatology Reports·Jacob N Ablin, Dan Buskila
Jan 1, 2012·Scientifica·Michael H Ossipov
Jan 8, 2015·The Journal of Headache and Pain·Lena Clara BeeseMartin Marziniak
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Jul 27, 2012·Headache·Isabel Pavão MartinsAntonio Gouveia Oliveira
Aug 18, 2018·Frontiers in Neurology·Antonio RussoGioacchino Tedeschi
Mar 27, 2020·Neural Regeneration Research·Xiao-Yan ChenSheng-Yuan Yu
Apr 19, 2013·Headache·Hadas Nahman-AverbuchIrit Weissman-Fogel
Jun 8, 2018·Molecular Neurobiology·Wei-Yi OngDeron R Herr
Aug 6, 2019·Frontiers in Integrative Neuroscience·Tami Bar-ShalitaIrit Weissman-Fogel
Jul 8, 2020·International Journal of Environmental Research and Public Health·Natalia KascakovaPeter Tavel

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