Oct 25, 2018

Orbitofrontal neuron ensembles contribute to inhibitory control

BioRxiv : the Preprint Server for Biology
Pragathi Priyadharsini Balasubramani, Benjamin Hayden

Abstract

Stopping, or inhibition, is a form of self-control that is a core part of adaptive behavior. We hypothesize that inhibition commands originate, in part, from the orbitofrontal cortex (OFC). We recorded activity of OFC neurons in macaques performing a stop signal task. Decoding analyses revealed a clear difference in ensemble responses that distinguish successful from failed inhibition that begins after the stop signal and before the stop signal reaction time. We also found a different and unrelated ensemble pattern that distinguishes successful from failed stopping before the beginning of the trial. These signals were distinct from, and orthogonal to, value encoding, which was also observed in these neurons. The timing of the early and late signals was, respectively, consistent with the idea that OFC contributes both proactively and reactively to inhibition. These results support the view, inspired by anatomy, that OFC gathers diverse sensory inputs to compute early-stage executive signals.

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Mentioned in this Paper

Patterns
Biological Regulation
Neurons
Executive Function
Orbitofrontal Cortex
Metabolic Inhibition
Clinical Trials
Analysis
Neuron of Cerebral Cortex
Structure of Orbital Gyrus

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