Orbitofrontal sulcogyral pattern and olfactory sulcus depth in the schizophrenia spectrum

European Archives of Psychiatry and Clinical Neuroscience
Yumiko NishikawaMichio Suzuki

Abstract

Morphological changes in the orbitofrontal cortex (OFC), such as an altered sulcogyral pattern of the 'H-shaped' orbital sulcus and a shallow olfactory sulcus, have been demonstrated in schizophrenia, possibly reflecting deviations in early neurodevelopment. However, it remains unclear whether patients with schizotypal features exhibit similar OFC changes. This magnetic resonance imaging study examined the OFC sulcogyral pattern (Types I, II, III, and IV) and olfactory sulcus morphology in 102 patients with schizophrenia, 47 patients with schizotypal disorder, and 84 healthy controls. The OFC sulcogyral pattern distribution between the groups was significantly different on the right hemisphere, with the schizophrenia patients showing a decrease in Type I (vs controls and schizotypal patients) and an increase in Type III (vs controls) expression. However, the schizotypal patients and controls did not differ in the OFC pattern. There were significant group differences in the olfactory sulcus depth bilaterally (schizophrenia patients < schizotypal patients < controls). Our findings suggest that schizotypal disorder, a milder form of schizophrenia spectrum disorders, partly shares the OFC changes (i.e., altered depth of the olfacto...Continue Reading

References

Jan 1, 1977·Annals of Neurology·J G ChiF H Gilles
Jan 1, 1995·Cerebral Cortex·E ArmstrongK Zilles
Jun 8, 2000·The Journal of Comparative Neurology·M M Chiavaras, M Petrides
Jan 28, 2003·Nature Neuroscience·Elizabeth R SowellArthur W Toga
Mar 21, 2003·Schizophrenia Bulletin·Adrian RainePatrick Colletti
Mar 3, 2004·The American Journal of Psychiatry·Larry J Siever, Kenneth L Davis
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Nov 13, 2004·European Archives of Psychiatry and Clinical Neuroscience·Yasuhiro KawasakiMasayoshi Kurachi
Apr 6, 2005·Archives of General Psychiatry·Jeffrey A LiebermanUNKNOWN HGDH Study Group
Jun 3, 2005·Brain : a Journal of Neurology·Michio SuzukiMasayoshi Kurachi
Mar 1, 2006·Schizophrenia Research·Tsutomu TakahashiMasayoshi Kurachi
Mar 10, 2007·Brain : a Journal of Neurology·Motoaki NakamuraMartha E Shenton
Aug 3, 2007·International Review of Psychiatry·C PantelisP D McGorry
Sep 16, 2008·Psychiatry Research·Tsutomu TakahashiMasayoshi Kurachi
Sep 22, 2009·Schizophrenia Research·Bruce I TuretskyPaul J Moberg
Jan 21, 2010·Psychological Medicine·J Moncrieff, J Leo
Jun 15, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·G ChakirovaA M McIntosh
Jul 6, 2011·Brain Imaging and Behavior·An D NguyenJames J Levitt
Sep 7, 2011·Archives of General Psychiatry·Neeltje E M van HarenRené S Kahn
Oct 19, 2011·Current Psychiatry Reports·Erin A HazlettJeanine C Kolaitis
Oct 16, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tsutomu TakahashiMichio Suzuki
Nov 20, 2012·Social Cognitive and Affective Neuroscience·Sarah WhittleNicholas B Allen
Dec 12, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gagan Fervaha, Gary Remington
Feb 7, 2013·Social Cognitive and Affective Neuroscience·Hiromi WatanabeRyuichiro Hashimoto
Mar 15, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cali F BartholomeuszStephen J Wood
Apr 6, 2013·The American Journal of Psychiatry·Nancy C AndreasenBeng-Choon Ho
Jul 9, 2013·Schizophrenia Research·Tsutomu TakahashiMichio Suzuki
Feb 18, 2014·Schizophrenia Research·Tsutomu TakahashiChristos Pantelis
Feb 25, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tsutomu TakahashiMichio Suzuki
Jun 26, 2014·Schizophrenia Bulletin·Marc S LenerErin A Hazlett

❮ Previous
Next ❯

Citations

Dec 10, 2015·European Archives of Psychiatry and Clinical Neuroscience·Andrea Schmitt, Peter Falkai
Mar 28, 2016·Psychiatry Research. Neuroimaging·Tsutomu TakahashiMichio Suzuki
Jun 23, 2016·Human Brain Mapping·Hyden ZhangIngrid R Olson
May 10, 2018·Psychological Medicine·Yoichiro TakayanagiMichio Suzuki
May 3, 2018·Psychiatry and Clinical Neurosciences·Tsutomu Takahashi, Michio Suzuki
Jun 6, 2019·Schizophrenia Bulletin·Yoichiro TakayanagiMichio Suzuki
Oct 10, 2019·Psychiatry and Clinical Neurosciences·Daiki SasabayashiMichio Suzuki
Aug 7, 2019·Translational Psychiatry·Yansong LiGuillaume Sescousse
Feb 8, 2020·Clinical EEG and Neuroscience·Motoaki NakamuraMartha E Shenton
Mar 25, 2018·European Archives of Psychiatry and Clinical Neuroscience·Mihoko NakamuraMichio Suzuki
Jan 16, 2021·Journal of Personalized Medicine·Tsutomu TakahashiMichio Suzuki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.