Orbivirus structure and assembly

Virology
P Roy

Abstract

Orbiviruses (Reoviridae family) are complex nonenveloped RNA viruses with seven structural proteins and a RNA genome consisting of 10 variously sized double-stranded RNA segments. Significant advances in orbivirus research have been made in recent years through the use of gene manipulation techniques coupled with the baculovirus expression system. Several orbivirus proteins have yielded to crystallization and X-ray crystallographic structure determination and, when combined with the three-dimensional image reconstruction of virion particles and cores obtained by cryoelectron microscopy, considerable insight has been gained into the intricate organization and topography of the individual viral components. Formal identification of the sites of interaction has been obtained through protein-protein interaction studies on the components of the virion particle, including those that are involved in capsid assembly. Finally, a beginning of the understanding of the sequence of assembly events has also been obtained.

Citations

Nov 2, 2012·Journal of Virology·Eiko Matsuo, Polly Roy
Aug 26, 2011·Journal of Virology·Marco CaporaleMassimo Palmarini
Oct 18, 2011·Emerging Infectious Diseases·Karin Aharonson-RazEyal Klement
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrew R BeatonPolly Roy
Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mario ForzanPolly Roy
Apr 21, 2009·Veterinary Microbiology·E ListesG Savini
Aug 1, 2008·Transboundary and Emerging Diseases·B Rodríguez-SánchezJ M Sánchez-Vizcaíno
Feb 27, 1999·Current Opinion in Structural Biology·L Liljas
Dec 3, 2014·Veterinary Microbiology·Maria Ana de la GrandièreÉtienne Thiry
Jan 24, 2017·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Gayle V WallVida van Staden
Jun 1, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kalpana AgnihotriGrant Campbell
Sep 4, 2001·Biotechnology & Genetic Engineering Reviews·J I Casal
Dec 31, 2020·Microorganisms·Luis Jiménez-CabelloAlejandro Marín-López
Apr 1, 1996·Current Opinion in Structural Biology·P Roy, I Jones

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