Orchestrating Opiate-Associated Memories in Thalamic Circuits.

Neuron
Piper C KeyesXiaoke Chen

Abstract

Disrupting memories that associate environmental cues with drug experiences holds promise for treating addiction, yet accessing the distributed neural network that stores such memories is challenging. Here, we show that the paraventricular nucleus of the thalamus (PVT) orchestrates the acquisition and maintenance of opiate-associated memories via projections to the central nucleus of the amygdala (CeA) and nucleus accumbens (NAc). PVT→CeA activity associates morphine reward to the environment, whereas transient inhibition of the PVT→NAc pathway during retrieval causes enduring protection against opiate-primed relapse. Using brain-wide activity mapping, we revealed distributed network activities that are altered in non-relapsing mice, which enabled us to find that activating the downstream NAc→lateral hypothalamus (LH) pathway also prevents relapse. These findings establish the PVT as a key node in the opiate-associated memory network and demonstrate the potential of targeting the PVT→NAc→LH pathway for treating opioid addiction.

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Citations

Dec 18, 2020·Pharmacology, Biochemistry, and Behavior·Yanaira Alonso-CaraballoElena H Chartoff
Jan 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lily R BarrettXiaobing Zhang
Sep 25, 2020·Neuron·Horia Pribiag, Byung Kook Lim
Nov 13, 2020·Frontiers in Behavioral Neuroscience·Jacqueline F McGinty, James M Otis
Mar 6, 2021·Frontiers in Behavioral Neuroscience·Kuikui ZhouYingjie Zhu
Mar 5, 2021·The European Journal of Neuroscience·Verónica Pastor, Jorge Horacio Medina
Mar 16, 2021·Frontiers in Behavioral Neuroscience·Sydney A Rowson, Kristen E Pleil
May 11, 2021·Frontiers in Integrative Neuroscience·Sarah M KarkMichael A Yassa
Jun 4, 2021·Frontiers in Behavioral Neuroscience·Cassandra L KooikerTallie Z Baram
Aug 3, 2021·Frontiers in Systems Neuroscience·Aurélie De Groote, Alban de Kerchove d'Exaerde
Aug 26, 2021·Cell Reports·Giuseppe GiannottiJamie Peters

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