Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury

The Journal of Immunology : Official Journal of the American Association of Immunologists
Hiroki KimuraM Nishimura

Abstract

Appropriate resolution of inflammation is known to be essential in tissue homeostasis. In this study, we evaluated the significance of a macrophage-derived soluble protein, apoptosis inhibitor of macrophage (AIM), in LPS-induced lung injury in mice. After oropharyngeal administration of LPS, the level of free-form serum AIM increased on days 2-4, accompanied by the resolution of inflammation, which was observed in the cellular profile of bronchoalveolar lavage fluid. In an experiment using wild-type (WT) and AIM-/- mice, the resolution of inflammation was accelerated in AIM-/- mice when compared with the WT mice, which was reversed when recombinant AIM protein was administered. The changes in the histopathological findings and inflammatory mediators followed similar trends, and the ratio of apoptotic cells was increased in AIM-/- mice when compared with the WT mice. In vitro analysis showed that macrophage phagocytosis of apoptotic neutrophils was suppressed in the presence of AIM, indicating that anti-resolution property of AIM involves efferocytosis inhibition. In lipidomic analysis of lung tissues, the levels of several lipid mediators increased markedly when LPS was given to WT mice. However, in AIM-/- mice, the concentrati...Continue Reading

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Citations

Oct 18, 2018·American Journal of Respiratory Cell and Molecular Biology·Xun GaoJu Cao
Feb 26, 2019·American Journal of Veterinary Research·Undine ChristmannPaul L Wood
Oct 30, 2020·Frontiers in Cell and Developmental Biology·Chuan-Chuan NanLixin Cheng
Mar 7, 2021·Cells·Peiyong ChengHuaiyong Chen
May 1, 2021·International Journal of Molecular Sciences·Lidia Sanchez-MoralMaria-Rosa Sarrias

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