Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses

Cellular & Molecular Immunology
Rama Krishna Gurram, Jinfang Zhu

Abstract

The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achieved to mount effective protection against invading pathogens while avoiding immunopathology. The classical model of type 2 immunity mainly involves the differentiation of type 2 T helper (Th2) cells and the production of distinct type 2 cytokines, including interleukin-4 (IL-4), IL-5, and IL-13. Group 2 innate lymphoid cells (ILC2s) were recently recognized as another important source of type 2 cytokines. Although eosinophils, mast cells, and basophils can also express type 2 cytokines and participate in type 2 immune responses to various degrees, the production of type 2 cytokines by the lymphoid lineages, Th2 cells, and ILC2s in particular is the central event during the type 2 immune response. In this review, we discuss recent advances in our understanding of how ILC2s and Th2 cells orchestrate type 2 immune responses through direct and indirect interactions.

References

May 1, 1991·The Journal of Allergy and Clinical Immunology·A B Kay
Apr 18, 1996·Nature·K TakedaS Akira
Jul 7, 1999·The Journal of Clinical Investigation·H WanC Robinson
Aug 23, 2000·The Journal of Clinical Investigation·B N LambrechtR A Pauwels
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A J McAdamG J Freeman
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Apr 12, 2001·European Journal of Immunology·L A StephensF Powrie
Jun 29, 2001·Nature Immunology·J A GonzaloA J Coyle
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S MiikeH Kita
Jun 6, 2002·Immunology·Marion Berard, David F Tough
Sep 20, 2002·The New England Journal of Medicine·Charlotte Braun-FahrländerUNKNOWN Allergy and Endotoxin Study Team
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nithiananthan AsokananthanGeoffrey A Stewart
Nov 6, 2002·The Journal of Allergy and Clinical Immunology·Rebecca S McHugh, Ethan M Shevach
Dec 18, 2002·The Journal of Experimental Medicine·Stephanie C EisenbarthKim Bottomly
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 23, 2005·The Journal of Experimental Medicine·Leonie S van RijtBart N Lambrecht
May 20, 2005·Cell and Tissue Research·Takuma SaitoMakoto Naito
Nov 9, 2005·The Journal of Experimental Medicine·Tomoki ItoYong-Jun Liu
Aug 15, 2006·Immunological Reviews·Maria Grazia RoncaroloMegan K Levings
Dec 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Annerose BerndtN Edward Robinson
Nov 17, 2007·Nature Reviews. Immunology·Robert M AnthonyWilliam C Gause
Feb 24, 2009·Advances in Immunology·Yong-Jun Liu
Jun 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki KouzakiHirohito Kita
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Liying GuoWilliam Paul
Sep 22, 2009·Immunity·Bart N Lambrecht, Hamida Hammad
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·Kelly D StoneDean D Metcalfe
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Mar 5, 2010·Nature·Daniel R NeillAndrew N J McKenzie

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Citations

Aug 9, 2020·Frontiers in Immunology·Yongyan Chen, Zhigang Tian
Sep 29, 2020·Frontiers in Immunology·Jingjing Cong
Feb 26, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Elizabeth R DaviesUNKNOWN U-BIOPRED Study Group
Sep 11, 2020·Experimental & Molecular Medicine·Hiroshi Ohno, Naoko Satoh-Takayama
Sep 10, 2019·Journal of Cellular and Molecular Medicine·Wenzhe ZhangXuefeng Wang
Sep 25, 2019·Expert Review of Clinical Immunology·Marco CaminatiLanny J Rosenwasser
May 6, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·James W KrempskiHirohito Kita
Aug 12, 2020·Nature Communications·Doumet Georges HelouOmid Akbari
Aug 5, 2020·Nature Immunology·Haiming Wei, Binqing Fu
Oct 13, 2020·Frontiers in Immunology·Sofía FrigerioTeresa Freire
Jun 27, 2020·The European Respiratory Journal·Celeste M PorsbjergElisabeth H Bel
Nov 1, 2020·International Journal of Molecular Sciences·Xiaoliang Zhu, Jinfang Zhu
Dec 31, 2020·International Journal of Molecular Sciences·Levi B RichardsBetty C A M van Esch
Oct 20, 2020·Frontiers in Immunology·Xunyao Wu
Apr 6, 2021·Frontiers in Immunology·Holger GarnPetra Ina Pfefferle
Apr 22, 2021·Acta Biomaterialia·Jefferson O AbariciaRene Olivares-Navarrete
May 20, 2021·Seminars in Immunopathology·Julien Catherine, Florence Roufosse
May 18, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·James R BakerJessica J O'Konek
Jul 22, 2021·Journal of Inflammation Research·Songwei Yang, Min Yu
Feb 6, 2021·The European Respiratory Journal·William W BusseMario Castro
Aug 22, 2021·Vaccine·Magdalena Kowalewicz-Kulbat, Camille Locht
Aug 27, 2021·Frontiers in Pharmacology·Maria Priscila SaracinoDaniel Horacio González Maglio
Jan 20, 2022·The Journal of Experimental Medicine·Gaoyu LiuJie Zhou
Jan 28, 2022·European Respiratory Review : an Official Journal of the European Respiratory Society·David J JacksonFlorence Roufosse

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Methods Mentioned

BETA
bronchoalveolar lavage

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