PMID: 8600087Mar 15, 1996Paper

Orchidectomy prior to definitive radiotherapy for localized prostatic cancer

International Journal of Radiation Oncology, Biology, Physics
N A SpryP E Morum

Abstract

To identify potential survival benefits of cytoreductive orchidectomy performed prior to definitive radiation for localized prostate cancer. Between 1977-1988, all patients with localized prostatic cancer from the Wellington Region received definitive radiotherapy (n = 200). One referring urologist Peter M. Meffen (P.M.M.) had commenced a program of prior orchidectomy followed by definitive radiation treatment (median time to radiation therapy was 5 months, n = 30). Five-year overall survival (OS) and relapse-free survival (RFS) for each stage were Stage A 82%, and 82%; Stage B 75%, and 61%; Stage C 57%, and 38%, respectively. Ten-year OS and RFS for each stage were Stage A 78%, and 72%; Stage B 51%, and 18%; Stage C 32% and 0%, respectively. Multivariate analysis identified prior orchidectomy treatment and histological grade as independently significant prognostic factors for OS and RFS. Factors influencing RFS were clinical stage, prior orchidectomy, and histological grade. Prior orchidectomy was associated with an increase in OS at 5 years when compared to those patients receiving radiotherapy alone, 86% vs. 69%, and maintained at 10 years, 82% vs. 46% (p < 0.05). The two groups were comparable by stage, histological grade, ...Continue Reading

References

Sep 1, 1977·International Journal of Radiation Oncology, Biology, Physics·W J NegliaD E Johnson
Jun 1, 1978·Cancer·L HarisiadisM Tannenbaum
Nov 1, 1976·International Journal of Radiation Oncology, Biology, Physics·B van der Werf-MessingD I Blonk
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·E M SoffenB E Epstein
May 1, 1992·British Journal of Urology·R J ShearerD P Dearnaley
Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
Sep 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C A PerezM A Lockett
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M V PilepichK L Martz
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsD H Hussey
Apr 1, 1987·International Journal of Radiation Oncology, Biology, Physics·G E HanksS Kramer
Aug 1, 1986·British Journal of Urology·P M Meffan, J N Nacey
Apr 1, 1985·International Journal of Radiation Oncology, Biology, Physics·E RosenJ T Chaffey
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·G E Hanks
Oct 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M V PilepichB J Walz
Jul 1, 1984·International Journal of Radiation Oncology, Biology, Physics·N GreenJ Jaffe
Oct 1, 1982·International Journal of Radiation Oncology, Biology, Physics·K K Ang, E van der Schueren
Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·G E Hanks

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.