Orchiectomized Fischer 344 male rat models body composition in hypogonadal state

Life Sciences
Stephen E Borst, Christine F Conover

Abstract

The hypogonadal state in men is accompanied by substantial decreases in muscle and bone mass and by an increase in adiposity. Most of the strains of orchiectomized (ORX) rat that have been used to model this state display substantial losses in bone, but only subtle changes in adiposity and muscle mass. In order to identify a rat model displaying a robust catabolic response to ORX, we studied three strains: Fischer 344 (F344), Brown Norway and Wistar. ORX caused a significant and sustained decrease in weight gained by F344, but only a trend toward reduced weight gain in Brown Norway rats and a modest reduction weight gain in Wistar rats that was significant only after 56days. ORX suppressed food intake in F344 rats, and to a lesser degree in Brown Norway and Wistar rats. ORX reduced muscle mass significantly in F344 rats, but not in Brown Norway or Wistar rats. ORX increased adiposity moderately in F344 rats and substantially in Wistar rats. ORX caused a marked reduction in prostate mass and increase in bone resorption in all three strains. Thus, F344 was the only strain in which ORX produced substantial decreases in food intake, body weight and muscle mass with increased adiposity and increased bone resorption. We conclude that...Continue Reading

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Citations

Aug 2, 2011·The British Journal of Nutrition·Satoru MakinoKiyoshi Ebihara
Sep 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Qianning JiaoCharles H Lang
Oct 17, 2012·PloS One·Joshua F YarrowStephen E Borst
Mar 26, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chi-Sung ChiuHilary A Wilkinson
Oct 7, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D G DonnerE F Du Toit
May 23, 2019·Journal of Molecular Neuroscience : MN·Taratorn FainantaSuchinda Malaivijitnond
Jan 13, 2010·Aging Clinical and Experimental Research·Sheau C Chai, Bahram H Arjmandi
Jan 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Joshua F YarrowStephen E Borst
Feb 24, 2015·Metabolic Brain Disease·Hiranya PintanaSiriporn Chattipakorn

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