Orchiectomy markedly reduces the concentration of the three isoforms of transforming growth factor beta in rat bone, and reduction is prevented by testosterone

Endocrinology
R K GillN H Bell

Abstract

Available evidence indicates that transforming growth factor beta (TGFbeta) is produced by bone cells, that production is enhanced by testosterone and dihydrotestosterone, and that TGFbeta is an important modulator of bone formation, induction, and repair. To determine the relative concentrations of isoforms of skeletal TGFbeta, whether orchiectomy alters the concentration of TGFbeta in long bones, and whether alteration is prevented by testosterone replacement, male Sprague-Dawley rats were either sham-operated and given placebo (n = 20) or orchiectomized and given either placebo (n = 20) or 100 mg testosterone (n = 20) by slow-release pellets implanted sc at the back of the neck and killed at 6 weeks. Orchiectomy did not change serum calcium and lowered serum testosterone and serum phosphorus; these reductions were prevented by testosterone replacement. TGFbeta1 in skeletal extracts was much more abundant than TGFbeta2 or TGFbeta3. Orchiectomy reduced skeletal TGFbeta by over 80 percent, and reduction was prevented by testosterone replacement. The relative abundance of the three isoforms of TGFbeta in bone was not influenced by orchiectomy or testosterone replacement, and skeletal messenger RNA of TGFbeta1 and TGFbeta2 was no...Continue Reading

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Citations

Sep 13, 2012·BMC Complementary and Alternative Medicine·Ahmad Nazrun ShuidIma Nirwana Soelaiman
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y OnoeT Suda
Jul 5, 2007·Histochemistry and Cell Biology·Branko FilipovićMilka Sekulić
Oct 27, 2006·Experimental Gerontology·Raymond W ThompsonJames A Carson
Jul 1, 2012·Asian-Australasian Journal of Animal Sciences·Cheng-Yung LinTien-Chun Wan
Feb 3, 2007·Kidney & Blood Pressure Research·Barry B McGuireNeil G Docherty
May 6, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Catherine R ThorpeColleen M Ryan
Jun 7, 2002·Endocrine Reviews·B Lawrence RiggsL Joseph Melton
Jun 8, 2004·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
Jun 16, 1999·Journal of Applied Physiology·R T TurnerT J Wronski
Feb 6, 2021·Journal of Clinical Medicine·Kazuyoshi ShigeharaAtsushi Mizokami

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